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NCT04421872
The Disorder of Circadian Clock Gene and Early Cognitive Dysfunction After General Anesthesia
NA trial testing receiving general anesthesia in Postoperative Delirium in 1,000 participants. Status unknown.
31 July 2022
Quick facts
| Lead sponsor | Shengjing Hospital |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | other |
| Enrollment | 1,000 |
| Start date | 1 July 2020 |
| Primary completion | 31 July 2022 |
| Estimated completion | 31 December 2023 |
| Sites | 1 location across China |
Drugs / interventions tested
- receiving general anesthesia
Conditions studied
- Postoperative Delirium — all drugs for Postoperative Delirium →
- General Anesthesia — all drugs for General Anesthesia →
- Exosomes — all drugs for Exosomes →
- Clock Gene — all drugs for Clock Gene →
Sponsor
Shengjing Hospital
Who can join
Adults 18 to 90, any sex, with Postoperative Delirium or General Anesthesia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Postoperative cognitive dysfunction (POCD) is a common postoperative complication in patients aged 65 and over, which refers to cognitive function changes such as memory decline and attention deficit after anesthesia and surgery. In severe cases, personality changes and social behavior decline may also occur, resulting in irreversible cognitive impairment.Previous studies have suggested that cognitive dysfunction after general anesthesia is linked to a genetic disorder of the body clock.Exosomes are cellular forms of cellular microvesicles containing complex RNA and proteins.Exosomes can mediate the expression of genes in the late transcriptional period of the clock system, and directly or indirectly participate in the negative regulation of rhythm expression of minute control genes, playing an important role in the intercellular circadian rhythm information output pathway.Rhythm disorders in the core biological clock system of urinary exosomes and the clock control genes related to kidney can early indicate circadian rhythm changes in the core biological clock system.The sorting and detection of urinary exosome clock information materials in patients has the advantages of easy access, continuous monitoring, early diagnosis and less damage, making urinary exosome a biomarker for the diagnosis and monitoring of circadian rhythm of a good kidney biological clock system.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
Clinical applications for exosomes: Are we there yet?
Perocheau D, Touramanidou L, Gurung S, Gissen P, et al · · 2021 · cited 101× · PMID 33751579 · DOI 10.1111/bph.15432 -
Insight into the Functional Dynamics and Challenges of Exosomes in Pharmaceutical Innovation and Precision Medicine.
Sharma A, Yadav A, Nandy A, Ghatak S. · · 2024 · cited 40× · PMID 38931833 · DOI 10.3390/pharmaceutics16060709 -
Global requirements for manufacturing and validation of clinical grade extracellular vesicles.
Thakur A, Rai D. · · 2024 · cited 24× · PMID 40027307 · DOI 10.1016/j.jlb.2024.100278
Verify or expand the search:
- PubMed search for NCT04421872
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04421872 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Shengjing Hospital
- Last refreshed: 9 June 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04421872.
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