NCT04407468 (APRONOX) is a clinical trial of Prone position in COVID, sponsored by Hospital General San Juan del Rio.

Who is sponsoring NCT04407468?

NCT04407468 is sponsored by Hospital General San Juan del Rio.

What drugs are being tested in NCT04407468?

Interventions in NCT04407468: Prone position.

What condition does NCT04407468 study?

NCT04407468 studies COVID, ARDS, Pneumonia.

Is NCT04407468 still recruiting?

NCT04407468 is currently completed. Last updated 15 July 2020.

Last reviewed 2020-07-15 · How we verify

NCT04407468: APRONOX

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Awake Prone Positioning and Oxygen Therapy in Patients With COVID-19

Completed Last updated 15 July 2020

What this trial tests

trial testing Prone position in COVID in 827 participants. Completed in 13 July 2020.

Timeline

1 May 2020

Primary endpoint
13 July 2020

13 July 2020

Quick facts

Lead sponsor	Hospital General San Juan del Rio
Status	Completed
Study type	OBSERVATIONAL
Enrollment	827
Start date	1 May 2020
Primary completion	13 July 2020
Estimated completion	13 July 2020
Sites	6 locations across Mexico

Drugs / interventions tested

Prone position

Conditions studied

COVID — all drugs for COVID →
ARDS — all drugs for ARDS →
Pneumonia — all drugs for Pneumonia →

Sponsor

Hospital General San Juan del Rio

Who can join

18 and older, any sex, with COVID or ARDS. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The prone position strategy for patients with acute respiratory distress syndrome (ARDS) is simple and cost-effective from the first description on its use in patients with acute respiratory failure to improve hypoxemia. Different studies have investigated its safety and efficacy in various clinical settings, demonstrating that its early use in combination with non-invasive mechanical ventilation (NIV) or high-flow oxygen therapy can reduce intubation rate and mortality in ARDS. In the Coronavirus disease 2019 (COVID-19) pandemic, high-value medicine and resource optimization are critical.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Awake prone positioning and oxygen therapy in patients with COVID-19: the APRONOX study.
Perez-Nieto OR, Escarraman-Martinez D, Guerrero-Gutierrez MA, Zamarron-Lopez EI, et al · · 2022 · cited 43× · PMID 34266942 · DOI 10.1183/13993003.00265-2021
Awake prone positioning and oxygen therapy in patients with COVID-19: The APRONOX study
Perez-Nieto OR, Escarraman-Martinez D, Guerrero-Gutierrez MA, Zamarron-Lopez EI, et al · · 2021 · cited 1× · DOI 10.1101/2021.01.27.21250631

Verify or expand the search:

Other trials of Prone position

Trials testing the same drug.

NCT07083973 — Prone Position Assessed by 3D EIT · recruiting
NCT07251777 — Prone vs Supine Position in Potential Organ Donors: Multicenter Clinical Trial · NA · completed
NCT04596202 — The Effect of Position on Gastric Residual Volume and Comfort Level in Newborns · NA · completed
NCT06076109 — Early Awake Alterning Prone Positioning Combined With Non-invasive Oxygen Therapy in Patients With COVID-19. · NA · terminated
NCT04904731 — Effects of Body Position on Diaphragmatic Activity in Patients Requiring Noninvasive Ventilation for Acute Respiratory F · completed

Other recruiting trials for COVID

Currently open trials in the same condition.

NCT06744660 — Clinical Validation of the Aptitude Medical Systems Metrix COVID-19 Test · NA · recruiting
NCT04910269 — Outpatient Treatment With Anti-Coronavirus Immunoglobulin · Phase 3 · recruiting
NCT04447833 — Mesenchymal Stromal Cell Therapy For The Treatment Of Acute Respiratory Distress Syndrome · Phase 1 · active not recruiting
NCT04351347 — The Efficacy of Ivermectin in Larger Doses in COVID-19 Treatment · Phase 2, PHASE3 · recruiting
NCT04382846 — Novel Regimens in COVID-19 Treatment · Phase 3 · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04407468 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Hospital General San Juan del Rio
Last refreshed: 15 July 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04407468.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing