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NCT04406441: ENCIRCLE

Patient-Clinic-Community Integration to Prevent Obesity Among Rural Preschool Children

Completed NA Results posted Last updated 5 March 2025
What this trial tests

NA trial testing Patient Reported Outcome Well Child Visit in Pediatric Obesity in 2,040 participants. Completed in 30 April 2024.

Timeline
17 August 2020
Primary endpoint
30 April 2024
30 April 2024

Quick facts

Lead sponsorGeisinger Clinic
PhaseNA
StatusCompleted
Study typeINTERVENTIONAL
Allocationrandomized
Designparallel
Maskingdouble
Primary purposeprevention
Enrollment2,040
Start date17 August 2020
Primary completion30 April 2024
Estimated completion30 April 2024
Sites1 location across United States

Drugs / interventions tested

Conditions studied

Sponsor

Geisinger Clinic

Who can join

Adults 20 Months to 59 Months, any sex, with Pediatric Obesity or Preventive Medicine. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Difference in BMI Z-score, Based on WHO Growth Standards Primary · 1-year

BMI values will be obtained from Geisinger clinical care visits, documented in the EHR and standardized or parent-reported. Values obtained at well child visits during the study period, ideally 12 months, 1 day apart will be utilized but values within a 9- to 18-month span of baseline to 1-year follow up may be used (e.g., 3 months pre-baseline WCV to 15 months post-baseline, baseline WCV to 18-months post-baseline, etc.) to assess the primary outcome. A z-score of 0 represents the population mean. Higher z-scores represent worse outcomes. BMI z-score over \>=1 indicates possible risk for over

GroupValue95% CI
Standard of Care1.005± 0.068
Patient Reported Outcome0.881± 0.066
Patient Reported Outcome + Food Care0.979± 0.073
United States Household Food Security Survey Module: Six-Item Short Form Secondary · 1-year

This questionnaire uses 6 items to provide a scale of food security of high food security to very low food security. Scoring: Responses of "often" or "sometimes" on questions Q1 and Q2, and "yes" on Q3, Q5, and Q6 are coded as affirmative (yes). Responses of "almost every month" and "some months but not every month" on Q4 are coded as affirmative (yes). The sum of affirmative responses to the six questions in the module is the household's raw score on the scale. Food security status is assigned as follows: Raw score 0-1-High or marginal food security (raw score 1 may be considered marginal foo

GroupValue95% CI
Standard of Care16.913.8 – 20.5
Patient Reported Outcome18.415.3 – 21.9
Patient Reported Outcome + Food Care21.417.6 – 25.8
Modified Version of Perceived Involvement in Care Scale Secondary · 1-year

The Modified Perceived Involvement in Care Scale (M-PICS) measures patients' perceptions of doctor-patient communication during the medical encounter. PICs includes 4 domains including 1-Health care provider information 2- Patient information 3- Patient decision making 4- Health care provider facilitation. The total score combines these 4 domains with a range from 20 poor-100 high reported at 12-month follow-up.

GroupValue95% CI
Standard of Care71.81± 0.72
Patient Reported Outcome71.99± 0.71
Patient Reported Outcome + Food Care72.92± 0.77
Food Resource Management Secondary · 1-year

Nine items from the Cooking Matters Food Resource Management survey that assess 2 subscales (each scored on 1-5 item Likert scale)- Food Resource Management Practices (indicating the frequency with which respondents engaged in behaviors to maximize food resources) and Food Resource Management Confidence (extent to which participants showed self-confidence in shopping, preparing foods, and managing food resources on a budget). Higher scores indicate more frequent practices and greater confidence, respectively. There is not a summary score. The scoring for each subscale uses the average of items

Food Resource Management Practices
GroupValue95% CI
Standard of Care3.76± 0.04
Patient Reported Outcome3.74± 0.04
Patient Reported Outcome + Food Care3.78± 0.04
Food Resource Management Confidence
GroupValue95% CI
Standard of Care3.96± 0.05
Patient Reported Outcome3.93± 0.05
Patient Reported Outcome + Food Care4.03± 0.05
Raw BMI Secondary · 1-year

Differences in raw BMI will be evaluated amongst study arms.

GroupValue95% CI
Standard of Care16.952± 0.114
Patient Reported Outcome16.735± 0.112
Patient Reported Outcome + Food Care16.967± 0.125
BMI Units Above the 50th Percentile (BMI50) Secondary · 1-year

Differences in BMI50 will be evaluated amongst study arms. We reported using mean number of BMI units from the population mean which is defined as the distance from the BMI for age and sex at the 50th %tile.

GroupValue95% CI
Standard of Care1.596± 0.114
Patient Reported Outcome1.373± 0.113
Patient Reported Outcome + Food Care1.609± 0.126
Percentage of Children Overweight and Obese Secondary · 1-year

Evaluate the percentage of children overweight and obese at 1-year follow-up per CDC guidance and definitions.

% Overweight
GroupValue95% CI
Standard of Care40.52
Patient Reported Outcome41.25
Patient Reported Outcome + Food Care41.54
% Obese
GroupValue95% CI
Standard of Care22.89
Patient Reported Outcome23.56
Patient Reported Outcome + Food Care22.85

Sponsor's own description

The goal of this research study is to compare two enhancements to well-child visits at Geisinger designed to promote family-centered counseling for the prevention of obesity in a high-risk population of rural, lower income, preschool-aged children. Compared to the standard well-child visit, enhancements will offer advantages to obesity prevention, parent involvement in counseling, lifestyle behaviors, and food resource management.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

  1. Comparing enhancements to well-child visits in the prevention of obesity: ENCIRCLE cluster-randomized controlled trial.
    Bailey-Davis L, Moore AM, Poulsen MN, Dzewaltowski DA, et al · · 2022 · cited 7× · PMID 36572870 · DOI 10.1186/s12889-022-14827-w
  2. Interventions to prevent obesity in children aged 2 to 4 years old.
    Phillips SM, Spiga F, Moore TH, Dawson S, et al · · 2025 · cited 3× · PMID 40494564 · DOI 10.1002/14651858.cd015326.pub2
  3. Agreement between parent-report and EMR height, weight, and BMI among rural children.
    Potts BA, Wood GC, Bailey-Davis L. · · 2024 · cited 1× · PMID 38496791 · DOI 10.3389/fnut.2024.1279931

Verify or expand the search:

Other recruiting trials for Pediatric Obesity

Currently open trials in the same condition.

Other Geisinger Clinic trials

Trials by the same sponsor.

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Data sources for this page

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04406441.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing