Last reviewed · How we verify
NCT06572345: LEGEND
Low EnerGy DiEt iN Adolescents With Obesity and Type 2 Diabetes: The LEGEND Study
NA trial testing Low-energy diet in Pediatric Obesity in 73 participants. Currently enrolling.
31 December 2026
Quick facts
| Lead sponsor | Nottingham University Hospitals NHS Trust |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 73 |
| Start date | 30 June 2025 |
| Primary completion | 31 December 2026 |
| Estimated completion | 31 December 2026 |
| Sites | 1 location across United Kingdom |
Drugs / interventions tested
- Low-energy diet
- Qualitive interview - LED participants
- Qualitive interview - Participants declining LED
- Qualitive interview - Health Care Professionals (HCPs)
Conditions studied
- Pediatric Obesity — all drugs for Pediatric Obesity →
- Type 2 Diabetes — all drugs for Type 2 Diabetes →
Sponsor
Nottingham University Hospitals NHS Trust
Who can join
Adults 12 to 17, any sex, with Pediatric Obesity or Type 2 Diabetes. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This is a multicentre, single-arm, feasibility study in adolescents with T2DM and obesity to investigate the recruitment and retention rates to a study using Low Energy Diets(LED). It will also provide estimates of weight loss needed to bring about remission to inform a larger randomised study. In addition a subgroup of participants and their parents/carers undertaking a period of LED will be interviewed to understand the participants experience of taking part. Two further groups will also be interviewed: participants and their parents/carers who have declined to take part in the LED to understand their motivations and barriers and healthcare practitioners who have participated in conducting the trial to understand their experience of the study.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06572345
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Low-energy diet
Trials testing the same drug.
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Other recruiting trials for Pediatric Obesity
Currently open trials in the same condition.
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- NCT07095166 — Monitoring Eating Across Locations (MEAL) - Timing, Intake, and Mealtime Evaluation (TIME) · NA · recruiting
- NCT07229508 — Developmental Trajectories of Reinforcer Pathology and Childhood Obesity · recruiting
- NCT06357299 — Assessing Better Bottles for Babies · NA · recruiting
Other Nottingham University Hospitals NHS Trust trials
Trials by the same sponsor.
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- NCT07036081 — A Single Arm Intervention Study to Assess the Acceptability, Tolerance and Ease of Use of Wilbo's Blends+ (Commercial En · NA · completed
- NCT07303569 — Prevention of Pressure Injury (PI) in Hospitalised Infants, Children, and Young People (CYP) (Aged 0-19 Years) · recruiting
- NCT07136298 — Seizure Identification on the Intensive Care Unit (ICU) · recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06572345 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Nottingham University Hospitals NHS Trust
- Last refreshed: 3 August 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06572345.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing