NCT04405934: COG-UK HOCI

COG-UK Project Hospital-Onset COVID-19 Infections Study

Completed NA Last updated 2 March 2022

What this trial tests

NA trial testing Use of virus (Covid-19) genome sequence report to inform infection prevention control procedures in Covid-19 in 2,170 participants. Completed in 8 October 2021.

Timeline

15 October 2020

Primary endpoint
26 April 2021

8 October 2021

Quick facts

Lead sponsor	University College, London
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	sequential
Masking	none
Primary purpose	health services research
Enrollment	2,170
Start date	15 October 2020
Primary completion	26 April 2021
Estimated completion	8 October 2021
Sites	1 location across United Kingdom

Drugs / interventions tested

• Use of virus (Covid-19) genome sequence report to inform infection prevention control procedures

Conditions studied

• Covid-19 — all drugs for Covid-19 →
• Nosocomial Infection — all drugs for Nosocomial Infection →
• Coronavirus — all drugs for Coronavirus →
• Coronavirus Infection — all drugs for Coronavirus Infection →

Sponsor

University College, London

Who can join

Eligibility, any sex, with Covid-19 or Nosocomial Infection. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Hospitals are recognised to be a major risk for the spread of infections despite the availability of protective measures. Under normal circumstances, staff may acquire and transmit infections, but the health impact of within hospital infection is greatest in vulnerable patients. For the novel coronavirus that causes COVID-19, like recent outbreaks such as the SARS and Ebola virus, the risk of within hospital spread of infection presents an additional, significant health risk to healthcare workers.

Infection Prevention and Control (IPC) teams within hospitals engage in practices that minimise the number of infections acquired within hospital. This includes surveillance of infection spread, and proactively leading on training to clinical and other hospital teams.

There is now good evidence that genome sequencing of epidemic viruses such as that which causes COVID-19, together with standard IPC, more effectively reduces within hospital infection rates and may help identify the routes of transmission, than just existing IPC practice. It is proposed to evaluate the benefit of genome sequencing in this context, and whether rapid (24-48h) turnaround on the data to IPC teams has an impact on that level of benefit.

The study team will ask participating NHS hospitals to collect IPC information as per usual practice for a short time to establish data for comparison. Where patients are confirmed to have a COVID-19 infection thought to have been transmitted within hospital, their samples will be sequenced with data fed back to hospital teams during the intervention phase. A final phase without the intervention may take place for additional information on standard IPC practice when the COVID-19 outbreak is at a low level nationwide.

Publications & conference data

6 peer-reviewed publications reference this trial (live from Europe PMC):

1. Rapid feedback on hospital onset SARS-CoV-2 infections combining epidemiological and sequencing data.
   Stirrup O, Hughes J, Parker M, Partridge DG, et al · · 2021 · cited 33× · PMID 34184637 · DOI 10.7554/elife.65828
2. Effectiveness of rapid SARS-CoV-2 genome sequencing in supporting infection control for hospital-onset COVID-19 infection: Multicentre, prospective study.
   Stirrup O, Blackstone J, Mapp F, MacNeil A, et al · · 2022 · cited 14× · PMID 36098502 · DOI 10.7554/elife.78427
3. Genetic epidemiology of SARS-CoV-2 transmission in renal dialysis units - A high risk community-hospital interface.
   Li KK, Woo YM, Stirrup O, Hughes J, et al · · 2021 · cited 10× · PMID 33895226 · DOI 10.1016/j.jinf.2021.04.020
4. Evaluating the cost implications of integrating SARS-CoV-2 genome sequencing for infection prevention and control investigation of nosocomial transmission within hospitals.
   Panca M, Blackstone J, Stirrup O, Cutino-Moguel MT, et al · · 2023 · cited 4× · PMID 37308063 · DOI 10.1016/j.jhin.2023.06.005
5. Evaluating the effectiveness of rapid SARS-CoV-2 genome sequencing in supporting infection control teams: the COG-UK hospital-onset COVID-19 infection study
   Stirrup O, Blackstone J, Mapp F, MacNeil A, et al · · 2022 · DOI 10.1101/2022.02.10.22270799
6. Genetic epidemiology of SARS-CoV-2 transmission in renal dialysis units - a high risk community-hospital interface
   Li KK, Woo YM, Stirrup O, Hughes J, et al · · 2021 · DOI 10.1101/2021.03.24.21253587