NCT04404725 is a NA clinical trial of comfilcon A in Astigmatism, sponsored by CooperVision, Inc..

Who is sponsoring NCT04404725?

NCT04404725 is sponsored by CooperVision, Inc..

What drugs are being tested in NCT04404725?

Interventions in NCT04404725: comfilcon A, Samfilcon A.

What condition does NCT04404725 study?

NCT04404725 studies Astigmatism, Presbyopia.

Is NCT04404725 still recruiting?

NCT04404725 is currently completed. Last updated 3 March 2022.

Are results published for NCT04404725?

Yes — primary outcome results have been posted to ClinicalTrials.gov. See the outcomes section above for details.

Last reviewed 2022-03-03 · How we verify

NCT04404725

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Comparing Biofinity Toric Multifocal to Ultra Multifocal for Astigmatism

Completed NA Results posted Last updated 3 March 2022

What this trial tests

NA trial testing comfilcon A in Astigmatism in 64 participants. Completed in 29 July 2021.

Timeline

6 August 2020

Primary endpoint
29 July 2021

29 July 2021

Quick facts

Lead sponsor	CooperVision, Inc.
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	single
Primary purpose	treatment
Enrollment	64
Start date	6 August 2020
Primary completion	29 July 2021
Estimated completion	29 July 2021
Sites	7 locations across Canada, United States

Drugs / interventions tested

comfilcon A — full drug profile →
Samfilcon A

Conditions studied

Astigmatism — all drugs for Astigmatism →
Presbyopia — all drugs for Presbyopia →

Sponsor

CooperVision, Inc.

Who can join

17 and older, any sex, with Astigmatism or Presbyopia. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Ease of Lens Handling at Insertion Primary · Day 28

Subjective at-home ratings for ease of lens handling for insertion, using a 0-10 scale (0-Very difficult, 10 - Very easy).

Group	Value	95% CI
Comfilcon A	8.6	± 1.6
Samfilcon A	8.8	± 1.8

Adverse events — posted to ClinicalTrials.gov

Time frame: One month on each study lenses, a total of two months.. Reporting threshold: 3%. Adverse-event reports describe events observed during the trial — not all are caused by the drug.

Comfilcon A

Serious: 0/61 (0%)

Deaths: 0/61

Samfilcon A

Serious: 0/63 (0%)

Deaths: 0/63

Other adverse events (3 terms — click to expand)

Reaction	System	Comfilcon A	Samfilcon A
conjunctivitis	Eye disorders	—	—
Non-Ocular Event	General disorders	—	—
Infiltrative Keratitis	Eye disorders	—	—

Data from ClinicalTrials.gov NCT04404725 adverse events section.

Sponsor's own description

The objective of the study was to compare the handling and performance of Biofinity Toric Multifocal to Ultra Multifocal for Astigmatism.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.

Verify or expand the search:

Other trials of comfilcon A

Trials testing the same drug.

NCT04195581 — A Clinical Evaluation of Two Contact Lenses Used With Three Care Systems · NA · completed
NCT04005885 — A Clinical Comparison of Two Daily Disposable Soft Contact Lenses · NA · completed
NCT02625233 — Clinical Long-Term Evaluation of Approved and Investigational Contact Lenses · NA · completed
NCT01180985 — Dispensing Evaluation of a Galyfilcon A Prototype Lens and a Marketed Contact Lens · NA · completed

Other recruiting trials for Astigmatism

Currently open trials in the same condition.

NCT07303920 — Wear Experience With Daily Disposable Contact Lenses for Astigmatism Over a Long-Wear Day · NA · recruiting
NCT07284966 — Comfort and Vision With TOTAL30 Multifocal Lenses · recruiting
NCT07078799 — Wavefront-guided LASIK Surgery Compared to Ray Tracing-Guided LASIK Surgery · NA · recruiting
NCT07084844 — Patient Reported Outcomes With WaveLight Plus LASIK · recruiting
NCT07140653 — Arcuate Incisions With Light Adjustable Lens for Astigmatism Correction in Lens Surgery · Phase 4 · recruiting

Other CooperVision, Inc. trials

Trials by the same sponsor.

NCT06817785 — Soft Lens Study: Biomedics 1 Day Extra Sphere and Clariti 1 Day Sphere · NA · completed
NCT06758076 — A Clinical Comparison of Two Soft Contact Lenses (C24-755) · NA · completed
NCT06590441 — Investigation of Wearing Compliance of Spectacles for Myopia Control · completed
NCT06609018 — Clinical Investigation of Buttermere (LENS 271) Soft Contact Lenses · NA · completed
NCT06611410 — 1 Week Crossover Study Between Two Soft Contact Lenses · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04404725 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by CooperVision, Inc.
Last refreshed: 3 March 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04404725.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing