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NCT04388670: 2019nCoV_ICU
Epidemiological and Clinical Characteristics of Critically Ill Patients With COVID-19
Status unknown
Last updated 14 May 2020
What this trial tests
trial in COVID-19 in 1,500 participants. Status unknown.
Timeline
22 February 2020
Primary endpoint
22 August 2020
22 August 2020
31 August 2020
Quick facts
| Lead sponsor | Policlinico Hospital |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 1,500 |
| Start date | 22 February 2020 |
| Primary completion | 22 August 2020 |
| Estimated completion | 31 August 2020 |
| Sites | 1 location across Italy |
Conditions studied
- COVID-19 — all drugs for COVID-19 →
- Critical Illness — all drugs for Critical Illness →
Sponsor
Policlinico Hospital
Who can join
18 and older, any sex, with COVID-19 or Critical Illness. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Objective of this observational multicentric retrospective-prospective study is to describe the number and the characteristics of patients with Reverse Transcription Polymerase Chain Reaction (RT-PCR) for SARS-CoV2 positivity admitted to Intensive Care Units during the first 6 months of epidemic.
Publications & conference data
8 peer-reviewed publications reference this trial (live from Europe PMC):
-
Hospital-Acquired Infections in Critically Ill Patients With COVID-19.
Grasselli G, Scaravilli V, Mangioni D, Scudeller L, et al · · 2021 · cited 263× · PMID 33857475 · DOI 10.1016/j.chest.2021.04.002 -
Prone position in intubated, mechanically ventilated patients with COVID-19: a multi-centric study of more than 1000 patients.
Langer T, Brioni M, Guzzardella A, Carlesso E, et al · · 2021 · cited 165× · PMID 33823862 · DOI 10.1186/s13054-021-03552-2 -
Time course of risk factors associated with mortality of 1260 critically ill patients with COVID-19 admitted to 24 Italian intensive care units.
Zanella A, Florio G, Antonelli M, Bellani G, et al · · 2021 · cited 52× · PMID 34373952 · DOI 10.1007/s00134-021-06495-y -
Impact of dexamethasone on the incidence of ventilator-associated pneumonia in mechanically ventilated COVID-19 patients: a propensity-matched cohort study.
Scaravilli V, Guzzardella A, Madotto F, Beltrama V, et al · · 2022 · cited 26× · PMID 35698155 · DOI 10.1186/s13054-022-04049-2 -
Genomic Characterization of Carbapenem-Resistant <i>Acinetobacter baumannii</i> (CRAB) in Mechanically Ventilated COVID-19 Patients and Impact of Infection Control Measures on Reducing CRAB Circulation during the Second Wave of the SARS-CoV-2 Pandemic in Milan, Italy.
Mangioni D, Fox V, Chatenoud L, Bolis M, et al · · 2023 · cited 18× · PMID 36976013 · DOI 10.1128/spectrum.00209-23 -
Successful Versus Failed Transition From Controlled Ventilation to Pressure Support Ventilation in COVID-19 Patients: A Retrospective Cohort Study.
Polo Friz M, Rezoagli E, Safaee Fakhr B, Florio G, et al · · 2024 · cited 6× · PMID 38343444 · DOI 10.1097/cce.0000000000001039 -
Biomarkers trajectories in critically ill patients with COVID-19 acute respiratory distress syndrome: insights from latent class growth analysis.
Madotto F, Ferrari F, Florio G, Guzzardella A, et al · · 2025 · cited 1× · PMID 41152846 · DOI 10.1186/s12890-025-03961-x -
Prone Position in Intubated, Mechanically Ventilated Patients with Coronavirus Disease-19.
Langer T, Brioni M, Guzzardella A, Carlesso E, et al · · 2021 · DOI 10.21203/rs.3.rs-191914/v1
Verify or expand the search:
- PubMed search for NCT04388670
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
Data sources for this page
- Trial protocol + status: ClinicalTrials.gov NCT04388670 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Policlinico Hospital
- Last refreshed: 14 May 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04388670.
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