NCT06312488 (POCEFIS) is a NA clinical trial of Clot Pro in Fibrinolytic Defect, sponsored by Policlinico Hospital.

Who is sponsoring NCT06312488?

NCT06312488 is sponsored by Policlinico Hospital.

What drugs are being tested in NCT06312488?

Interventions in NCT06312488: Clot Pro.

What condition does NCT06312488 study?

NCT06312488 studies Fibrinolytic Defect, Sepsis, Critical Illness.

Is NCT06312488 still recruiting?

NCT06312488 is currently completed. Last updated 8 April 2026.

Last reviewed 2026-04-08 · How we verify

NCT06312488: POCEFIS

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Point of Care Evaluation of Fibrinolysis in Sepsis

Completed NA Last updated 8 April 2026

What this trial tests

NA trial testing Clot Pro in Fibrinolytic Defect in 100 participants. Completed in 30 November 2025.

Timeline

22 January 2024

Primary endpoint
31 March 2025

30 November 2025

Quick facts

Lead sponsor	Policlinico Hospital
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	non randomized
Design	parallel
Masking	none
Primary purpose	diagnostic
Enrollment	100
Start date	22 January 2024
Primary completion	31 March 2025
Estimated completion	30 November 2025
Sites	1 location across Italy

Drugs / interventions tested

Clot Pro

Conditions studied

Fibrinolytic Defect — all drugs for Fibrinolytic Defect →
Sepsis — all drugs for Sepsis →
Critical Illness — all drugs for Critical Illness →

Sponsor

Policlinico Hospital

Who can join

18 and older, any sex, with Fibrinolytic Defect or Sepsis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Impaired fibrinolysis in septic patients is associated with worse outcome. The present study investigates fibrinolysis shutdown in septic patients, defined as prolonged ClotPro® TPA lysis time at 30 minutes. The TPA lysis time reference range is established in a cohort of healthy volunteers.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Abstracts of the ICARE 2025 79th SIAARTI National Congress.
· 2025 · PMID 41111139 · DOI 10.1186/s44158-025-00273-8

Verify or expand the search:

Other Policlinico Hospital trials

Trials by the same sponsor.

NCT06848010 — TRacheal Cuff PRessure Evaluation Study · NA · not yet recruiting
NCT06583642 — Antimicrobial Therapeutic Drug Monitoring During Lung Transplant Perioperative Phase · not yet recruiting
NCT06302192 — Renal Doppler to Predict Acute Kidney Injury (AKI) in ARDS Patients. (RED-AKI Study) · not yet recruiting
NCT06395259 — Observational Study on the Variation of Ascorbic Acid in Patients Undergoing Solid Organ Transplantation · active not recruiting
NCT05691205 — Identifying Optimal PEEP After Lung Transplantation · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT06312488 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Policlinico Hospital
Last refreshed: 8 April 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06312488.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing