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NCT04387513: ICE-COCA
Impact of Early Cardiac Surgery in Severe Left Endocarditis With Neurological Complications: a Retrospective Study
trial testing Cardiac surgery in Endocarditis in 192 participants. Completed in 31 December 2017.
18 August 2010
Quick facts
| Lead sponsor | Gros, Alexandre, M.D. |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 192 |
| Start date | 1 August 2010 |
| Primary completion | 18 August 2010 |
| Estimated completion | 31 December 2017 |
Drugs / interventions tested
- Cardiac surgery
Conditions studied
- Endocarditis — all drugs for Endocarditis →
- Neurologic Complication — all drugs for Neurologic Complication →
Sponsor
Gros, Alexandre, M.D.
Who can join
18 and older, any sex, with Endocarditis or Neurologic Complication. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Surgical delay in severe endocardits, with neurological complications, is still debated. Early surgery, if indicated, permits to avoid new embolic events, or to fix valvular damages, but can create or increase a cerebral hemorrage. Hypothesis Cardiac surgery, as soon as possible, if indicated, would reduce mortality, in severe left endocarditis, with neurological complications. Primary objective To assess the impact of early versus late cardiac surgery on mortality at 1 year, in patients with severe endocarditis, with neurological complications. Primary endpoint: 1\) Mortality at 1 year Secondary endpoints: 1. Analyze the factors associated with neurological degradation 2. Evaluate the neurological tolerance of cardiac surgery.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT04387513
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
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- Google Scholar
Related trials
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- NCT06554925 — SEx-specific Differences in Cardiac Surgery Patients (SECS). · recruiting
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Other recruiting trials for Endocarditis
Currently open trials in the same condition.
- NCT05139589 — The ENDOCARDITIS AUMC Data Collection · recruiting
- NCT05547607 — Clinical and Diagnostic Features of Endocarditis · recruiting
- NCT05146180 — Interest of Parametric Positron Emission Imaging in the Diagnosis of Infections on Cardiac Valve Prosthesis · NA · recruiting
- NCT06403839 — Impact of Preoperative Dental Screening in Reducing Infective Endocarditis Risk in Surgical Valve Replacement Patients · recruiting
- NCT03892174 — Cytokine REmoval in CRitically Ill PAtients Requiring Surgical Therapy for Infective Endocarditis (RECReATE) · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04387513 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Gros, Alexandre, M.D.
- Last refreshed: 19 May 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04387513.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing