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NCT04373824
Max Ivermectin- COVID 19 Study Versus Standard of Care Treatment for COVID 19 Cases. A Pilot Study
NA trial testing Ivermectin in COVID in 50 participants. Status unknown.
25 July 2020
Quick facts
| Lead sponsor | Max Healthcare Insititute Limited |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | crossover |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 50 |
| Start date | 25 April 2020 |
| Primary completion | 25 July 2020 |
| Estimated completion | 25 July 2020 |
| Sites | 1 location across India |
Drugs / interventions tested
- Ivermectin (ivermectin) — full drug profile →
Conditions studied
- COVID — all drugs for COVID →
Sponsor
Max Healthcare Insititute Limited
Who can join
Adults 18 to 75, any sex, with COVID. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
At present, there are no specific treatments for COVID-19. WHO recommends four treatments for COVID 19 with drugs i.eRemdesivir, Lopinavir/ ritonavir, Lopinavir/ ritonavir with interferon beta -1a, and chloroquine or hydroxychloroquine. Currently, there are several ongoing clinical trials evaluating potential treatments. Recently, LeonCaly reported that Ivermectin, an FDA-approved anti-parasitic previously shown to have broad-spectrum anti-viral activity in vitro, is an inhibitor of the causative virus (SARS-CoV-2), with a single addition to Vero-hSLAM cells 2 hours post infection with SARSCoV-2 able to effect about 5000-fold reduction in viral RNA at 48 h. Ivermectin therefore warrant further investigation for possible benefits in humans. The study rationale is to understand the effect of the drug on eradication of virus.
Publications & conference data
8 peer-reviewed publications reference this trial (live from Europe PMC):
-
Ivermectin as a potential drug for treatment of COVID-19: an in-sync review with clinical and computational attributes.
Kaur H, Shekhar N, Sharma S, Sarma P, et al · · 2021 · cited 52× · PMID 33389725 · DOI 10.1007/s43440-020-00195-y -
Ivermectin as a Broad-Spectrum Host-Directed Antiviral: The Real Deal?
Jans DA, Wagstaff KM. · · 2020 · cited 52× · PMID 32942671 · DOI 10.3390/cells9092100 -
Ivermectin: an award-winning drug with expected antiviral activity against COVID-19.
Formiga FR, Leblanc R, de Souza Rebouças J, Farias LP, et al · · 2021 · cited 48× · PMID 33038449 · DOI 10.1016/j.jconrel.2020.10.009 -
Ivermectin: potential candidate for the treatment of Covid 19.
Gupta D, Sahoo AK, Singh A. · · 2020 · cited 36× · PMID 32615072 · DOI 10.1016/j.bjid.2020.06.002 -
Ivermectin for preventing and treating COVID-19.
Popp M, Reis S, Schießer S, Hausinger RI, et al · · 2022 · cited 30× · PMID 35726131 · DOI 10.1002/14651858.cd015017.pub3 -
The broad spectrum host-directed agent ivermectin as an antiviral for SARS-CoV-2 ?
Jans DA, Wagstaff KM. · · 2021 · cited 26× · PMID 33341233 · DOI 10.1016/j.bbrc.2020.10.042 -
COVID-19 associated complications and potential therapeutic targets.
Monpara JD, Sodha SJ, Gupta PK. · · 2020 · cited 21× · PMID 32926918 · DOI 10.1016/j.ejphar.2020.173548 -
Pharmacological insight into potential therapeutic agents for the deadly Covid-19 pandemic.
Bhandari R, Khanna G, Kuhad A. · · 2021 · cited 13× · PMID 33065092 · DOI 10.1016/j.ejphar.2020.173643
Verify or expand the search:
- PubMed search for NCT04373824
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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- NCT05605925 — Ivermectin-artemisinin Combination Therapy for Eradication of Malaria · Phase 4 · unknown
- NCT05045937 — Observational Study on the Use of Ivermectin as an Outpatient Treatment Option for COVID-19 · unknown
- NCT05643820 — Comparison of Oral Ivermectin and Permethrin 5% Lotion in Treatment of Pediculosis Capitis · Phase 1 · completed
Other recruiting trials for COVID
Currently open trials in the same condition.
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Other Max Healthcare Insititute Limited trials
Trials by the same sponsor.
- NCT07496333 — The Effect of Virtual Reality Distraction on Pain During Colonoscopy · NA · completed
- NCT06456216 — Performance Evaluation of Diagnostic Accuracy of PanTum Detect Test for Detection of Solid Tumours in Known Cancer Popul · completed
- NCT04422379 — COVID-19 and Liver Injury in Patients With or Without Underlying Liver Disease: A Multi-centre Retrospective-prospective · unknown
- NCT04469660 — Impact of COVID-19 Pandemic on the Psychological Wellbeing of Healthcare Professionals in India · unknown
- NCT04374487 — Assess the Safety and Efficacy of Convalescent Plasma to Limit COVID-19 Associated Complications · Phase 2 · unknown
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04373824 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Max Healthcare Insititute Limited
- Last refreshed: 4 May 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04373824.
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