NCT04358900 (UnMASCK) is a clinical trial in Mood Disorders, sponsored by University of Illinois at Chicago.

Who is sponsoring NCT04358900?

NCT04358900 is sponsored by University of Illinois at Chicago.

What condition does NCT04358900 study?

NCT04358900 studies Mood Disorders, Major Depressive Disorder, Bipolar Disorder I, Bipolar Disorder II, Persistent Depressive Disorder (Dysthymia), Cyclothymia.

Is NCT04358900 still recruiting?

NCT04358900 is currently active, enrolled. Last updated 4 September 2025.

Last reviewed 2025-09-04 · How we verify

NCT04358900: UnMASCK

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Unobtrusive Monitoring of Affective Symptoms and Cognition Using Keyboard Dynamics (UnMASCK)

Active, enrolled Last updated 4 September 2025

What this trial tests

trial in Mood Disorders in 132 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

17 September 2020

Primary endpoint
31 March 2025

30 November 2025

Quick facts

Lead sponsor	University of Illinois at Chicago
Status	Active, enrolled
Study type	OBSERVATIONAL
Enrollment	132
Start date	17 September 2020
Primary completion	31 March 2025
Estimated completion	30 November 2025
Sites	1 location across United States

Conditions studied

Mood Disorders — all drugs for Mood Disorders →
Major Depressive Disorder — all drugs for Major Depressive Disorder →
Bipolar Disorder I — all drugs for Bipolar Disorder I →
Bipolar Disorder II — all drugs for Bipolar Disorder II →

Sponsor

University of Illinois at Chicago

Who can join

Adults 25 to 50, any sex, with Mood Disorders or Major Depressive Disorder. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Mood disorders are associated with significant financial and health costs for the United States, partially due to cognitive problems in these patients that can worsen disease course and impair treatment response. This study proposes to use smartphone-based technology to monitor cognitive problems in patients with mood disorders by linking brain network changes with predicted worsening of mood symptoms. The proposed study will provide evidence for using smartphone-based passive sensing as a cost-effective way to predict illness course and treatment response.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Assessment of cognitive function in bipolar disorder with passive smartphone keystroke metadata: a BiAffect digital phenotyping study.
Ajilore O, Bark JS, Demos AP, Zulueta J, et al · · 2025 · cited 2× · PMID 40115651 · DOI 10.3389/fpsyt.2025.1430303
Keying Into Cognition: Temporal Smoothing of Smartphone Typing Behaviors for Passive Assessment of Processing Speed and Executive Function in Individuals With Mood Disorders.
Ross MK, Tulabandhula T, Nguyen TM, Ning E, et al · · 2026 · cited 1× · PMID 41938101 · DOI 10.1007/s12559-026-10549-y
A heterotrimeric G protein (Gsα) biomarker may predict antidepressant response in subjects with major depressive disorder.
Targum SD, Gunay A, Leow A, Ajilore OA, et al · · 2025 · PMID 40756308 · DOI 10.3389/fpsyt.2025.1619243

Verify or expand the search:

Other recruiting trials for Mood Disorders

Currently open trials in the same condition.

NCT07523490 — Investigation on Suicide Risk Factors of Patients With Mood Disorders · recruiting
NCT07362511 — Imagery Rescripting in Primary Care · NA · recruiting
NCT07211750 — Integrated Care for Older Adults With Major Depression and Physical Multimorbidity - The I-CONNECT · NA · recruiting
NCT07088939 — Feasibility and Acceptability of an E-learning Dialectical Behavior Therapy Skills Course · NA · recruiting
NCT06412315 — 7T Amygdala and Citalopram Study · NA · recruiting

Other University of Illinois at Chicago trials

Trials by the same sponsor.

NCT07498322 — Chicago Data-driven Opioid Use Disorder Screening, Engagement, Treatment and Planning System · NA · not yet recruiting
NCT07387705 — On Track for Wellness (OTW) Stepped Wedge Cluster Randomized Trial · Phase 1 · not yet recruiting
NCT07504120 — The Effect of Remotely Delivered Pilates on Physical , and Psychological Outcomes in Individuals With Multiple Sclerosis · NA · not yet recruiting
NCT07160582 — Cognitive-Motor Training for AD/ADRD Prevention · NA · not yet recruiting
NCT07498348 — Apple Watch Evaluation of Endodontics Occupational Stress · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04358900 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Illinois at Chicago
Last refreshed: 4 September 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04358900.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing