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NCT04327427
Outcome Analysis of Aspirin in Liver Transplantation
trial testing Aspirin in Liver Transplant; Complications in 3,000 participants. Status unknown.
1 October 2020
Quick facts
| Lead sponsor | University of Zurich |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 3,000 |
| Start date | 1 October 2019 |
| Primary completion | 1 October 2020 |
| Estimated completion | 31 May 2021 |
| Sites | 1 location across Switzerland |
Drugs / interventions tested
- Aspirin — full drug profile →
Conditions studied
- Liver Transplant; Complications — all drugs for Liver Transplant; Complications →
Sponsor
University of Zurich
Who can join
18 and older, any sex, with Liver Transplant; Complications. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
In the experimental setting inhibition of platelet activation was able to reduce immune-mediated necroinflammatory liver disease and consecutively hepatocellular carcinoma development. Therefore, antiplatelet therapy may not only have a preventive effect on hepatic artery patency but also on tumor recurrence. So far and to the best of our knowledge, no study investigated the effect of antiplatelet therapy on hepatic arterial patency, tumor recurrence and graft survival after primary liver transplantation.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Low-dose aspirin confers protection against acute cellular allograft rejection after primary liver transplantation.
Oberkofler CE, Raptis DA, Müller PC, Sousa da Silva RX, et al · · 2022 · cited 13× · PMID 35735232 · DOI 10.1002/lt.26534 -
Aspirin in hepatocellular carcinoma: Is it an out-of-date or promising treatment?
Qiu X, Gao F, Wang K, Zhang Z, et al · · 2022 · PMID 40636145 · DOI 10.1016/j.iliver.2022.03.003
Verify or expand the search:
- PubMed search for NCT04327427
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Aspirin
Trials testing the same drug.
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- NCT07431762 — Comparison of Anti-Thrombotic Treatments Between Aspirin and Warfarin During Initial Six Months After Bioprpsthetic Hear · Phase 4 · not yet recruiting
- NCT07373756 — Randomized Controlled Study to Compare Efficacy of Aspirin 75mg and 150mg In the Prevention of Preeclampsia In High Risk · Phase 4 · not yet recruiting
- NCT07180472 — Prevention of Stroke Recurrence and Disease Progression in Cerebral Small Vessel Disease With Cilostazol · Phase 4 · not yet recruiting
- NCT06638151 — Clopidogrel Plus Aspirin in Acute Ischemic Stroke Following Thrombectomy and/or Intravenous Thrombolysis (CoPrime) · Phase 2 · recruiting
Other recruiting trials for Liver Transplant; Complications
Currently open trials in the same condition.
- NCT06257407 — Perioperative Hemostasis Management in Liver Transplantation · recruiting
- NCT06533592 — The Effect of the Type of Conduit-duct Anastomosis Technique on the Postoperative Course in Patients Undergoing Liver Tr · NA · recruiting
- NCT06400771 — Safety of DNP007 in Healthy Subjects · Phase 1 · recruiting
- NCT06386198 — HEalth Advocate for Liver Transplantation: Improving Transition of Care for Adolescent Liver Transplant Recipients · NA · recruiting
- NCT06236568 — Impact of Graft Reconditioning With Hypothermic Machine Perfusion on HCC Recurrence After Liver Transplantation · NA · recruiting
Other University of Zurich trials
Trials by the same sponsor.
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- NCT07516912 — Evaluation of Free STI Testing Pilot Projects in Lucerne and Zurich, Switzerland · not yet recruiting
- NCT07473115 — Individualized Analgesia in the Intensive Care Unit With a New Pain Assessment Bundle and Protocolized Analgesia Adjustm · not yet recruiting
- NCT07524023 — Emotional-distress-based Integrated Care Programme in Patients With Stable COPD · NA · recruiting
- NCT06481982 — Value of Advanced MRI Techniques in the Assessment of Endometriosis · withdrawn
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04327427 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Zurich
- Last refreshed: 31 March 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04327427.
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