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NCT06257407: HEMOTRANSPLANT
Perioperative Hemostasis Management in Liver Transplantation
trial in Liver Transplant; Complications in 1,200 participants. Currently enrolling.
30 October 2026
Quick facts
| Lead sponsor | Société Française d'Anesthésie et de Réanimation |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 1,200 |
| Start date | 17 October 2024 |
| Primary completion | 30 October 2026 |
| Estimated completion | 31 December 2026 |
| Sites | 16 locations across France |
Conditions studied
- Liver Transplant; Complications — all drugs for Liver Transplant; Complications →
Sponsor
Société Française d'Anesthésie et de Réanimation
Who can join
18 and older, any sex, with Liver Transplant; Complications. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Liver transplantation (LT) is a surgery with risk of bleeding. Several risk factors have been identified: complex dissection, portal hypertension, history of ascites fluid infections, history of surgical procedures, pre-existing complex hemostatic disorders and those acquired during the procedure. Diffuse bleeding can occur at any time during the 3 phases of surgery: dissection, anhepatic and neohepatic. However, intraoperative bleeding and transfusion requirements remain difficult to predict. Current predictive models are based in particular on preoperative characteristics and do not take into account the course and different phases of the operation. The need for transfusions has largely decreased over the last 20 years, and currently around 20-25% of patients are transfused (transfusion of at least 1 blood product during LT). However, massive transfusion is necessary in 10% of LT. The European Society of Anaesthesiology (ESA) has issued recommendations on the management of severe bleeding during surgery. However, these recommendations are not specific to LT. Moreover, transfusion strategies vary widely from one center to another. The implementation of protocols within teams dedicated to LT has led to a reduction in bleeding and transfusion, with or without the use of viscoelastic testing. Intraoperative bleeding and transfusion requirements, as well as postoperative thromboembolic complications, remain difficult to predict. Predictive models of bleeding risk have been developed, but they are based solely on preoperative characteristics and do not take into account the course and various phases of the operation. In addition, new methods such as Bayesian inference or machine learning have been developed, and seem capable of providing different information from that obtained by conventional models. The overall aim of this prospective multicenter observational study is to investigate the risk factors for bleeding and thrombosis in per- and post-operative LT using different predictive methods, and to describe the management of bleeding and post-operative anticoagulation in metropolitan France.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06257407
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Liver Transplant; Complications
Currently open trials in the same condition.
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- NCT06236568 — Impact of Graft Reconditioning With Hypothermic Machine Perfusion on HCC Recurrence After Liver Transplantation · NA · recruiting
- NCT03789383 — Risk Factors and Outcome of Biliary Complications Following Adult Living Donor Liver Transplantation · recruiting
Other Société Française d'Anesthésie et de Réanimation trials
Trials by the same sponsor.
- NCT07526220 — Prognostic Factors in Critically Ill Patients Admitted After Caustic Ingestion in France · not yet recruiting
- NCT07317635 — Impact of Implementing a National Classification of Surgical Emergencies on Postoperative Morbidity and Mortality: a Pro · not yet recruiting
- NCT07182916 — Factors Associated With Early Readmission in Critical Care · recruiting
- NCT06768515 — ICU Management of Brain-Dead Donors Before Multi-Organ Procurement and Factors Associated With the Number of Organs Retr · recruiting
- NCT06487442 — Management of Postoperative Pain in France: a Prospective National Study · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06257407 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Société Française d'Anesthésie et de Réanimation
- Last refreshed: 2 April 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06257407.
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