Who is sponsoring NCT04326985?

NCT04326985 is sponsored by Chinese University of Hong Kong.

What drugs are being tested in NCT04326985?

Interventions in NCT04326985: Autologous Mesenchymal Stem Cells Treatment (MSCs), Hyaluronic acid (HA).

What condition does NCT04326985 study?

NCT04326985 studies Osteoarthritis, Knee.

Is NCT04326985 still recruiting?

NCT04326985 is currently completed. Last updated 18 May 2020.

Last reviewed 2020-05-18 · How we verify

NCT04326985: MSC

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

RCT Mesenchymal Stem Cells Versus Hyaluronic Acid in OA Knee):

Completed EARLY_PHASE1 Last updated 18 May 2020

What this trial tests

EARLY_PHASE1 trial testing Autologous Mesenchymal Stem Cells Treatment (MSCs) in Osteoarthritis, Knee in 20 participants. Completed in 28 February 2019.

Timeline

31 January 2015

Primary endpoint
30 January 2019

28 February 2019

Quick facts

Lead sponsor	Chinese University of Hong Kong
Phase	EARLY_PHASE1
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	20
Start date	31 January 2015
Primary completion	30 January 2019
Estimated completion	28 February 2019
Sites	1 location across Hong Kong

Drugs / interventions tested

Autologous Mesenchymal Stem Cells Treatment (MSCs) — full drug profile →
Hyaluronic acid (HA) — full drug profile →

Conditions studied

Osteoarthritis, Knee — all drugs for Osteoarthritis, Knee →

Sponsor

Chinese University of Hong Kong

Who can join

Adults 18 to 65, any sex, with Osteoarthritis, Knee. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of this study is to evaluate the therapeutic effect of adult autologous mesenchymal stem cells (abbreviated as MSCs) in patients with osteoarthritic knee and compare to intra articular injection of Synvisc-One.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

Clinical Trials Based on Mesenchymal Stromal Cells are Exponentially Increasing: Where are We in Recent Years?
Galderisi U, Peluso G, Di Bernardo G. · · 2022 · cited 175× · PMID 34398443 · DOI 10.1007/s12015-021-10231-w
The Current Status of Clinical Trials on Biologics for Cartilage Repair and Osteoarthritis Treatment: An Analysis of ClinicalTrials.gov Data.
Zhang Z, Schon L. · · 2022 · cited 21× · PMID 35546280 · DOI 10.1177/19476035221093065
Accentuating the sources of mesenchymal stem cells as cellular therapy for osteoarthritis knees-a panoramic review.
Muthu S, Jeyaraman M, Jain R, Gulati A, et al · · 2021 · cited 14× · PMID 34386542 · DOI 10.21037/sci-2020-055
Stem cell injections for osteoarthritis of the knee.
Whittle SL, Johnston RV, McDonald S, Worthley D, et al · · 2025 · cited 11× · PMID 40169165 · DOI 10.1002/14651858.cd013342.pub2

Verify or expand the search:

Other recruiting trials for Osteoarthritis, Knee

Currently open trials in the same condition.

NCT07509307 — AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee · Phase 3 · recruiting
NCT06488144 — Rehabilitation for Arthritis of The Knee: mainTaining Improvement for Veterans · Phase 3 · recruiting
NCT07386561 — Virtual Reality Therapy and Non-Sleep Deep Rest Relaxation After Joint Arthroplasty · NA · active not recruiting
NCT07514598 — Effect of J-Shaped Incision After Total Knee Arthroplasty (J-TKA) · NA · active not recruiting
NCT07058623 — Nurse-Led Telehealth vs In-Person Follow-Up After Total Knee Replacement · NA · recruiting

Other Chinese University of Hong Kong trials

Trials by the same sponsor.

NCT07508644 — RSV Vaccination to Reduce Recurrent AECOPD · Phase 4 · not yet recruiting
NCT07230457 — Plasma MTB cfDNA Before Bronchoscopy · not yet recruiting
NCT07288671 — Nostalgia Intervention on Alleviating Loneliness Amongst Older Adults · NA · not yet recruiting
NCT07256457 — Postoperative Pulmonary Function Assessment Based on Deep Learning Study · NA · not yet recruiting
NCT06904209 — Can Artificial Intelligence Reduce Consumption of Standard High Volume Bowel Preparation Regimen Among Older Population, · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04326985 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Chinese University of Hong Kong
Last refreshed: 18 May 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04326985.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing