NCT04313010 is a NA clinical trial of PRF in Pulp Necrosis, sponsored by Southern Medical University, China.

Who is sponsoring NCT04313010?

NCT04313010 is sponsored by Southern Medical University, China.

What drugs are being tested in NCT04313010?

Interventions in NCT04313010: PRF, BC.

What condition does NCT04313010 study?

NCT04313010 studies Pulp Necrosis.

Is NCT04313010 still recruiting?

NCT04313010 is currently status unknown. Last updated 23 March 2020.

Last reviewed 2020-03-23 · How we verify

NCT04313010

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Effectiveness of Regenerative Endodontics Therapy for Single-rooted Mature Permanent Tooth With Pulp Necrosis

Status unknown NA Last updated 23 March 2020

What this trial tests

NA trial testing PRF in Pulp Necrosis in 346 participants. Status unknown.

Timeline

16 March 2020

Primary endpoint
30 June 2024

30 June 2024

Quick facts

Lead sponsor	Southern Medical University, China
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	346
Start date	16 March 2020
Primary completion	30 June 2024
Estimated completion	30 June 2024
Sites	3 locations across China

Drugs / interventions tested

PRF — full drug profile →
BC

Conditions studied

Pulp Necrosis — all drugs for Pulp Necrosis →

Sponsor

Southern Medical University, China

Who can join

Adults 10 to 59, any sex, with Pulp Necrosis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study is to evaluate the effectiveness of regenerative endodontics therapy in single-rooted permanent teeth with pulp necrosis，and compare the clinical efficacy of platelet rich fibrin (PRF) and blood clot (BC) as scaffolds.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Efficacy of i-PRF in regenerative endodontics therapy for mature permanent teeth with pulp necrosis: study protocol for a multicentre randomised controlled trial.
Liang Y, Ma R, Chen L, Dai X, et al · · 2021 · cited 17× · PMID 34229752 · DOI 10.1186/s13063-021-05401-7

Verify or expand the search:

Other trials of PRF

Trials testing the same drug.

NCT06787677 — SPG Pulsed Radiofrequency for Chronic Cluster Headache · NA · recruiting
NCT06834802 — 3D Analysis of Soft Tissue Healing After Immediate Implant Placement Using PRF Vs HAM · NA · active not recruiting
NCT05816707 — The Assessment of Curcuma Longa Potentials for Soft and Hard Tissue Healing in Fresh · Phase 1 · completed
NCT06406530 — Topical Application of PRF Before Radiation Therapy · NA · recruiting
NCT05890157 — Treatment Of Shallow Periodontal Pockets Using PRF As an Adjunct To Scaling And Root Planing In Periodontitis Patients · NA · unknown

Other recruiting trials for Pulp Necrosis

Currently open trials in the same condition.

NCT07091981 — Effect of Rotary File Number on MB2 Canal Negotiation and Postoperative Pain · NA · recruiting
NCT07391124 — In Vivo Pulp Thermal Changes During Different Slenderization Techniques · NA · active not recruiting

Other Southern Medical University, China trials

Trials by the same sponsor.

NCT06813963 — Minoxidil for Treating White Hair: A Randomized Controlled Trial · Phase 4 · recruiting
NCT06218524 — The Effectiveness of HP and TMZ Synergism on Adult Recurrence GBM · Phase 2 · not yet recruiting
NCT05754554 — Clinical Study of the Treatment of Chiari Malformation Combined With Type II Skull Base Depression · NA · unknown
NCT05476874 — Improvement of Peritoneal Catheter Placement in VPS With a Splitable Trocar · Phase 1, PHASE2 · unknown
NCT04691453 — QM-B and QM-C Hysterectomy for Early Cervical Cancer · NA · unknown

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04313010 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Southern Medical University, China
Last refreshed: 23 March 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04313010.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing