60 and older, any sex, with Healthy Aging or Alzheimer Disease. Patients with the condition only — healthy volunteers not accepted.
Results — posted to ClinicalTrials.gov
Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.
Fluorodeoxyglucose (FDG) Positron Emission Tomography (PET) Metabolism (Standard Uptake Value Ratio)Primary· Resting Vs acute exercise bout: ~1 month
FDG PET measures reflecting cerebral metabolism standardized to the uptake value of the cerebellum and standardized uptake value ratios (SUVR) calculated from native-space region of interest (ROI).
Group
Value
95% CI
Moderate Intensity Aerobic Exercise
-0.0514
± 0.03
High Intensity Aerobic Exercise
-0.0667
± 0.03
Lactate Area Under the CurveSecondary· Resting Vs acute exercise bout: ~1 month
Change in lactate AUC between the resting and exercise condition
The overall goal is to characterize the acute exercise response as it relates to brain glucose metabolism in aging and Alzheimer's Disease (AD). The study team will also examine lactate metabolism, relationships with cognition, and the effect of exercise intensity.
Publications & conference data
6 peer-reviewed publications reference this trial (live from Europe PMC):
NCT07517224 — Assessing the Effect of an Aerobic Exercise Program on Vascular Function in Women With Non-Metastatic Breast Cancer
· NA
· not yet recruiting
NCT07444333 — Cardiac Output and Fatigue in Friedreich's Ataxia
· NA
· not yet recruiting
NCT07182006 — Exercise as Medicine for Pediatric Chronic Pain
· NA
· not yet recruiting
NCT07404319 — Effectiveness of Exercise Alone and tDCS+Exercise on Cognitive Function Improvement in Patients With Treatment Resistant
· NA
· not yet recruiting
NCT07302204 — Efficacy of Aerobic Exercise Versus Therapeutic Exercises on Exercise-induced Hypoalgesia in Knee Osteoarthritis
· NA
· recruiting
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Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Kansas Medical Center
Last refreshed: 23 July 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04299308.