NCT04296565: WATER-Vet

Water-based Activity to Enhance Recall in Veterans

Active, enrolled Phase 4 Last updated 17 August 2025

What this trial tests

Phase 4 trial testing Usual Care in Mild Cognitive Impairment in 121 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

3 January 2022

Primary endpoint
31 March 2026

30 June 2026

Quick facts

Lead sponsor	VA Office of Research and Development
Phase	Phase 4
Status	Active, enrolled
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	121
Start date	3 January 2022
Primary completion	31 March 2026
Estimated completion	30 June 2026
Sites	1 location across United States

Drugs / interventions tested

• Usual Care
• WATER+CT

Conditions studied

• Mild Cognitive Impairment — all drugs for Mild Cognitive Impairment →

Sponsor

VA Office of Research and Development — full company profile →

Who can join

Adults 50 to 90, any sex, with Mild Cognitive Impairment. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This four-year study will evaluate the efficacy of an exercise training augmentation for cognitive training intervention to improve memory performance in Veterans with a diagnosis of amnestic Mild Cognitive Impairment (aMCI). This is a two-phased trial: 1) an exercise phase and 2) a cognitive training program. The exercise phase will be an aquatic based exercise program. A combination of exercise and cognitive training programs designed for persons without cognitive impairment have significantly improved memory more than other single intervention groups (exercise only, cognitive training only) and given the success of combination training programs with healthy older adults, it is important to adapt these programs for persons beginning to exhibit clinically significant memory problems, such as those with aMCI.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.