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NCT04288531: IodineMinho
Iodine Impact on Thyroid Function and Psychomotor Development, Observational Study in the Portuguese Minho Region
trial testing Iodine supplementation in Iodine Deficiency in 304 participants. Participants enrolled and being followed up; not accepting new ones.
10 January 2024
Quick facts
| Lead sponsor | University of Minho |
|---|---|
| Status | Active, enrolled |
| Study type | OBSERVATIONAL |
| Enrollment | 304 |
| Start date | 10 January 2020 |
| Primary completion | 10 January 2024 |
| Estimated completion | 10 January 2026 |
| Sites | 10 locations across Portugal |
Drugs / interventions tested
- Iodine supplementation
Conditions studied
- Iodine Deficiency — all drugs for Iodine Deficiency →
- Thyroid — all drugs for Thyroid →
- Pregnancy Related — all drugs for Pregnancy Related →
- Psychomotor Impairment — all drugs for Psychomotor Impairment →
Sponsor
University of Minho
Who can join
Adults 18 to 50, female only, with Iodine Deficiency or Thyroid. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Full intellectual capabilities are achieved only if crucial nutrients are present during development. Iodine deficiency is the most common cause of preventable brain harm in infants. Because of its critical need during pregnancy, several countries implemented programs of iodine supplementation in preconception and pregnancy. In 2013, the prevalence of iodine deficiency in Portugal has led health authorities to issue a recommendation for iodine supplementation. This study aims to evaluate the impact of iodine supplementation on maternal and fetal iodine status and thyroid function, obstetric outcomes, quality of breast milk and child psychomotor development. It also intends to evaluate whether the time of iodine supplementation initiation influences all the above-mentioned parameters. The novelty and relevance of this study reside on the number of women/child and on the extent of health parameters that will be evaluated. The information collected will contribute to the detailed characterization of thyroid hormone homeostasis throughout pregnancy and its relationship with iodine supplementation (including time of initiation). The data will provide evidence on whether this iodine supplementation strategy impacted on iodine sufficiency of the mother and the newborns, or if it needs re-evaluation.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Impact of iodine supplementation during preconception, pregnancy and lactation on maternal thyroid homeostasis and offspring psychomotor development: protocol of the IodineMinho prospective study.
Lopes-Pereira M, Roque S, Costa P, Quialheiro A, et al · · 2020 · cited 9× · PMID 33187482 · DOI 10.1186/s12884-020-03376-y
Verify or expand the search:
- PubMed search for NCT04288531
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04288531 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Minho
- Last refreshed: 15 November 2024
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