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NCT04287881
Methylenetetrahydrofolate Reductase Deficiency in Ischemic Stroke
NA trial testing Methylenetetrahydrofolate reductase (MTHFR) deficiency in Hyperhomocysteinemia, Thrombotic, Cbs-Related in 32 participants. Completed in 20 February 2020.
15 February 2020
Quick facts
| Lead sponsor | Istanbul Medeniyet University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | screening |
| Enrollment | 32 |
| Start date | 31 October 2019 |
| Primary completion | 15 February 2020 |
| Estimated completion | 20 February 2020 |
| Sites | 2 locations across Turkey (Türkiye) |
Drugs / interventions tested
- Methylenetetrahydrofolate reductase (MTHFR) deficiency
Conditions studied
- Hyperhomocysteinemia, Thrombotic, Cbs-Related — all drugs for Hyperhomocysteinemia, Thrombotic, Cbs-Related →
- Ischemic Stroke — all drugs for Ischemic Stroke →
- Epilepsy — all drugs for Epilepsy →
Sponsor
Istanbul Medeniyet University
Who can join
Eligibility, any sex, with Hyperhomocysteinemia, Thrombotic, Cbs-Related or Ischemic Stroke. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Adult onset epileptic seizures is rare and often associated with metabolic disorders, drugs and intracranial pathologies such as ischemia, hemorrhage or space-occupying lesions. Methylenetetrahydrofolate reductase (MTHFR) deficiency is one of the reasons that cause epileptic seizures in adults and can be ignored. MTHFR deficiency is an autosomal recessive disorder that results in hyperhomocysteinemia and causes a predisposition to venous and arterial thrombosis. The incidence of the polymorphism is around 40% in some countries. The aim of the retrospective study is to investigate the incidence of MTHFR deficiency in patients with adult-onset epileptic seizures.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT04287881
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04287881 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Istanbul Medeniyet University
- Last refreshed: 27 February 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04287881.
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