NCT04278027 is a NA clinical trial of Cognitive Remediation Therapy in Schizophrenia, sponsored by Hospital Clinic of Barcelona.

Who is sponsoring NCT04278027?

NCT04278027 is sponsored by Hospital Clinic of Barcelona.

What drugs are being tested in NCT04278027?

Interventions in NCT04278027: Cognitive Remediation Therapy.

What condition does NCT04278027 study?

NCT04278027 studies Schizophrenia.

Is NCT04278027 still recruiting?

NCT04278027 is currently status unknown. Last updated 20 February 2020.

Last reviewed 2020-02-20 · How we verify

NCT04278027

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Cognitive Remediation Therapy in Schizophrenia: Effects on Epigenetics

Status unknown NA Last updated 20 February 2020

What this trial tests

NA trial testing Cognitive Remediation Therapy in Schizophrenia in 60 participants. Status unknown.

Timeline

3 January 2017

Primary endpoint
5 May 2020

15 June 2020

Quick facts

Lead sponsor	Hospital Clinic of Barcelona
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	60
Start date	3 January 2017
Primary completion	5 May 2020
Estimated completion	15 June 2020
Sites	1 location across Spain

Drugs / interventions tested

Cognitive Remediation Therapy

Conditions studied

Schizophrenia — all drugs for Schizophrenia →

Sponsor

Hospital Clinic of Barcelona

Who can join

Adults 18 to 60, any sex, with Schizophrenia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study is a randomised and controlled trial that aims to investigate whether Cognitive Remediation Therapy (CRT) can modulate epigenetic mechanisms by changing methylation levels of BDNF gene in patients with Schizophrenia.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Changes in BDNF methylation patterns after cognitive remediation therapy in schizophrenia: A randomized and controlled trial.
Penadés R, Almodóvar-Payá C, García-Rizo C, Ruíz V, et al · · 2024 · cited 5× · PMID 38537483 · DOI 10.1016/j.jpsychires.2024.03.014

Verify or expand the search:

Other trials of Cognitive Remediation Therapy

Trials testing the same drug.

NCT06936397 — Cognitive Remediation Therapy for Schizophrenia: Effects on EEG and Emotional Regulation · NA · recruiting
NCT03974620 — Individual Placement and Support and/or Cognitive Remediation Therapy Added to TAU in Patients With Early Schizophrenia · NA · not yet recruiting
NCT06989151 — Cognitive Remediation for Autistic Adolescents · EARLY_PHASE1 · completed
NCT05017831 — Shifting Perspectives R33 Phase: Enhancing Outcomes in Anorexia Nervosa With CRT · NA · completed
NCT02950506 — Transcranial Direct Current Stimulation and Cognitive Remediation Therapy for Interictal Dysfunction in Epilepsy · NA · withdrawn

Other recruiting trials for Schizophrenia

Currently open trials in the same condition.

NCT07424404 — A Study to Evaluate the Long-term Safety and Tolerability of KarXT and KarX-EC for the Treatment of Schizophrenia and Au · Phase 3 · recruiting
NCT07467993 — Study to Assess the Safety, Tolerability, and Treatment Response of GXV813 in Hospitalized Adults With Schizophrenia · Phase 2 · recruiting
NCT07379827 — Effectiveness and Adverse-effect Switch Evaluation of Xanomeline and Trospium Chloride (KarXT) · recruiting
NCT06758414 — CBT-CP for Veterans With SMI · NA · recruiting
NCT07395206 — Acceptability, Feasibility and Preliminary Outcomes of the Kiso Mind App for Outpatients With Schizophrenia Spectrum Dis · NA · recruiting

Other Hospital Clinic of Barcelona trials

Trials by the same sponsor.

NCT07509814 — Extended Versus Short Prehabilitation Programme for Patients With Advanced Ovarian Cancer Undergoing Major Surgery · NA · not yet recruiting
NCT07469358 — iCBT for Adolescents Obsessive-compulsive Dissorder · NA · active not recruiting
NCT07358611 — Non-invasive Mapping-Guided Atrial Fibrillation Ablation · NA · recruiting
NCT07237867 — Frequency-Dependent Effects of Percutaneous Femoral Nerve Stimulation on Quadriceps Strength in Athletes With Patellar T · NA · recruiting
NCT07163936 — Analysis of the Influence of Dialysis Fluid Composition on Vascular Calcification in Patients With Chronic Kidney Diseas · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04278027 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Hospital Clinic of Barcelona
Last refreshed: 20 February 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04278027.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing