Who is sponsoring NCT04277650?

NCT04277650 is sponsored by Duke University.

What drugs are being tested in NCT04277650?

Interventions in NCT04277650: Machine learning algorithm.

What condition does NCT04277650 study?

NCT04277650 studies Radiation Therapy Complication, Chemotherapeutic Toxicity.

Is NCT04277650 still recruiting?

NCT04277650 is currently completed. Last updated 19 May 2021.

Last reviewed 2021-05-19 · How we verify

NCT04277650: SHIELD-RT

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

System for High-Intensity Evaluation During Radiotherapy

Completed NA Last updated 19 May 2021

What this trial tests

NA trial testing Machine learning algorithm in Radiation Therapy Complication in 311 participants. Completed in 30 June 2019.

Timeline

7 September 2018

Primary endpoint
30 June 2019

30 June 2019

Quick facts

Lead sponsor	Duke University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	supportive care
Enrollment	311
Start date	7 September 2018
Primary completion	30 June 2019
Estimated completion	30 June 2019
Sites	1 location across United States

Drugs / interventions tested

Machine learning algorithm

Conditions studied

Radiation Therapy Complication — all drugs for Radiation Therapy Complication →
Chemotherapeutic Toxicity — all drugs for Chemotherapeutic Toxicity →

Sponsor

Duke University

Who can join

18 and older, any sex, with Radiation Therapy Complication or Chemotherapeutic Toxicity. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This quality improvement project will evaluate the implementation of a previously described intervention (twice per week on-treatment clinical evaluations) in a feasible fashion using a previously described machine learning algorithm identifying patients identified at high risk for an emergency visit or hospitalization during radiation therapy.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

System for High-Intensity Evaluation During Radiation Therapy (SHIELD-RT): A Prospective Randomized Study of Machine Learning-Directed Clinical Evaluations During Radiation and Chemoradiation.
Hong JC, Eclov NCW, Dalal NH, Thomas SM, et al · · 2020 · cited 70× · PMID 32886536 · DOI 10.1200/jco.20.01688
Implementation of machine learning in the clinic: challenges and lessons in prospective deployment from the System for High Intensity EvaLuation During Radiation Therapy (SHIELD-RT) randomized controlled study.
Hong JC, Eclov NCW, Stephens SJ, Mowery YM, et al · · 2022 · cited 7× · PMID 36180836 · DOI 10.1186/s12859-022-04940-3
Health Care Cost Reductions with Machine Learning-Directed Evaluations during Radiation Therapy - An Economic Analysis of a Randomized Controlled Study.
Natesan D, Eisenstein EL, Thomas SM, Eclov NCW, et al · · 2024 · cited 5× · PMID 38586278 · DOI 10.1056/aioa2300118
Artificial Intelligence in Oncology: A 10-Year ClinicalTrials.gov-Based Analysis Across the Cancer Control Continuum.
Verma H, Mistry S, Jayam KV, Shrestha P, et al · · 2025 · PMID 41228330 · DOI 10.3390/cancers17213537

Verify or expand the search:

Other trials of Machine learning algorithm

Trials testing the same drug.

NCT06029452 — A Retrospective Validation Study To Identify Chart-Based Clinical Diagnosis Of Wild-Type Transthyretin Amyloid Cardiomyo · completed
NCT05122247 — Machine Learning to Predict Acute Care During Cancer Therapy · completed

Other recruiting trials for Radiation Therapy Complication

Currently open trials in the same condition.

NCT05907681 — Prospective Observational Study on Outcome of High-precision Hypo-fractionated Radiotherapy in Metastatic Breast Cancer · recruiting
NCT05218824 — Collection of Head Images During Radiotherapy · active not recruiting

Other Duke University trials

Trials by the same sponsor.

NCT07216456 — Vaginal Dilator Therapy After Pelvic Radiation · NA · not yet recruiting
NCT07519317 — Dosing and Deployment Trial: A Home-based Optokinetic Treatment · NA · not yet recruiting
NCT07275359 — Investigating Senolytic Properties in Pulmonary Rehabilitation and Metformin in COPD Exacerbations · Phase 1 · not yet recruiting
NCT07216963 — The Community Paramedic Response and Overdose Outreach With Supportive Medical-Legal Services Study · NA · not yet recruiting
NCT07459218 — IDEAS for Hope to Reduce Suicide Risk and Improve HIV Care Engagement in Tanzania · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04277650 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Duke University
Last refreshed: 19 May 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04277650.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing