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NCT05122247: Chemo-SHIELD
Machine Learning to Predict Acute Care During Cancer Therapy
trial testing Machine learning algorithm in Chemotherapeutic Toxicity in 12,000 participants. Completed in 19 September 2023.
19 September 2023
Quick facts
| Lead sponsor | Duke University |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 12,000 |
| Start date | 3 January 2022 |
| Primary completion | 19 September 2023 |
| Estimated completion | 19 September 2023 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Machine learning algorithm
Conditions studied
- Chemotherapeutic Toxicity — all drugs for Chemotherapeutic Toxicity →
Sponsor
Duke University
Who can join
18 and older, any sex, with Chemotherapeutic Toxicity. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The objective of this study is to apply a validated machine-learning based model (SHIELD-RT, NCT04277650) to a cohort of patients undergoing systemic therapy as outpatient cancer treatment to generate an automatic system for the prediction of unplanned hospital admission rates and emergency department encounters.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Artificial Intelligence in Oncology: A 10-Year ClinicalTrials.gov-Based Analysis Across the Cancer Control Continuum.
Verma H, Mistry S, Jayam KV, Shrestha P, et al · · 2025 · PMID 41228330 · DOI 10.3390/cancers17213537
Verify or expand the search:
- PubMed search for NCT05122247
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Machine learning algorithm
Trials testing the same drug.
- NCT06029452 — A Retrospective Validation Study To Identify Chart-Based Clinical Diagnosis Of Wild-Type Transthyretin Amyloid Cardiomyo · completed
- NCT04277650 — System for High-Intensity Evaluation During Radiotherapy · NA · completed
Other recruiting trials for Chemotherapeutic Toxicity
Currently open trials in the same condition.
- NCT06387901 — Investigating Paclitaxel Toxicity in Breast Cancer: the Roles of Physical Activity and Body Composition. · recruiting
- NCT06270667 — Effects of Exercise Training in Survivors of Lymphoma · NA · recruiting
- NCT06197581 — Safety Assessment of Concurrent Radiotherapy and Novel Systemic Therapy for Breast Cancer · NA · recruiting
- NCT06826534 — At-Home Cardiac Rehabilitation for Adolescents at Risk for Heart Failure · NA · recruiting
- NCT06421610 — OPC5: Pressurized IntraThoracic Aerosol Chemotherapy (PITAC) in Patients With Malignant Pleural Effusion. · Phase 1 · recruiting
Other Duke University trials
Trials by the same sponsor.
- NCT07216456 — Vaginal Dilator Therapy After Pelvic Radiation · NA · not yet recruiting
- NCT07519317 — Dosing and Deployment Trial: A Home-based Optokinetic Treatment · NA · not yet recruiting
- NCT07275359 — Investigating Senolytic Properties in Pulmonary Rehabilitation and Metformin in COPD Exacerbations · Phase 1 · not yet recruiting
- NCT07216963 — The Community Paramedic Response and Overdose Outreach With Supportive Medical-Legal Services Study · NA · not yet recruiting
- NCT07459218 — IDEAS for Hope to Reduce Suicide Risk and Improve HIV Care Engagement in Tanzania · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05122247 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Duke University
- Last refreshed: 21 September 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05122247.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing