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NCT04277390
microRNA 155 Levels and Periodontal Microflora (Bacteria and Virus) in Preeclampsia.
trial testing clinical intervention for microbial analysis and MIR155 as biomarker in Preeclampsia in 445 participants. Completed in 10 November 2019.
20 August 2018
Quick facts
| Lead sponsor | Meenakshi Ammal Dental College and Hospital |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 445 |
| Start date | 1 August 2015 |
| Primary completion | 20 August 2018 |
| Estimated completion | 10 November 2019 |
| Sites | 1 location across India |
Drugs / interventions tested
- clinical intervention for microbial analysis and MIR155 as biomarker
Conditions studied
- Preeclampsia — all drugs for Preeclampsia →
- Chronic Periodontitis — all drugs for Chronic Periodontitis →
Sponsor
Meenakshi Ammal Dental College and Hospital
Who can join
Adults 18 to 35, female only, with Preeclampsia or Chronic Periodontitis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Preeclamptic women with and without chronic periodontitis were recruited for the study. Subgingival plaque samples and placental tissue samples(postpartum) were obtained from the participants for the microbial analysis(bacteria, viruses) and MIR155 levels and comparison was done among groups. this study was designed in order to evaluate the role of periodontal microorganisms in preeclampsia and to find compare the MIR155 levels among participants, so as to check its importance as a biomarker for inflammatory disease like preeclampsia.
Publications & conference data
5 peer-reviewed publications reference this trial (live from Europe PMC):
-
MicroRNA-155 Implication in M1 Polarization and the Impact in Inflammatory Diseases.
Pasca S, Jurj A, Petrushev B, Tomuleasa C, et al · · 2020 · cited 56× · PMID 32351507 · DOI 10.3389/fimmu.2020.00625 -
Oxidative Stress and MicroRNAs in Endothelial Cells under Metabolic Disorders.
Minjares M, Wu W, Wang JM. · · 2023 · cited 30× · PMID 37174741 · DOI 10.3390/cells12091341 -
Role of Periodontal Bacteria, Viruses, and Placental <i>mir155</i> in Chronic Periodontitis and Preeclampsia-A Genetic Microbiological Study.
Mahendra J, Mahendra L, Mugri MH, Sayed ME, et al · · 2021 · cited 21× · PMID 34449559 · DOI 10.3390/cimb43020060 -
Noncoding RNAs as Promising Diagnostic Biomarkers and Therapeutic Targets in Intestinal Fibrosis of Crohn's Disease: The Path From Bench to Bedside.
Zhou LY, Lin SN, Rieder F, Chen MH, et al · · 2021 · cited 11× · PMID 33324986 · DOI 10.1093/ibd/izaa321 -
Advances in the roles and mechanisms of mesenchymal stem cell derived microRNAs on periodontal tissue regeneration.
Zhang J, Chen L, Yu J, Tian W, et al · · 2024 · cited 2× · PMID 39491017 · DOI 10.1186/s13287-024-03998-5
Verify or expand the search:
- PubMed search for NCT04277390
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Preeclampsia
Currently open trials in the same condition.
- NCT06953115 — Vagal Stimulation Therapy and Preeclampsia · NA · recruiting
- NCT06333652 — Ravulizumab in Pregnancies Complicated by Severe Hypertensive Disorders · Phase 2 · recruiting
- NCT07282171 — A Study to Investigate the Safety, Pharmacodynamic and Pharmacokinetic Characteristics of CBP-4888 in Hospitalized Parti · Phase 1 · recruiting
- NCT07345845 — MR and Inflammation After Preeclampsia · EARLY_PHASE1 · active not recruiting
- NCT07041281 — Spironolactone to Improve Pregnancy-Associated Hypertension Trajectories · Phase 2 · recruiting
Other Meenakshi Ammal Dental College and Hospital trials
Trials by the same sponsor.
- NCT07504744 — Klotho Gene, Red Complex Bacteria and Periodontal Viruses in Patients With and Without Periodontitis and Acute Coronary · not yet recruiting
- NCT07353606 — Cofilin-2 (rs80358250) and Lactoferrin (rs1126478) Polymorphism and Protein Levels With Non Surgical Periodontal Therapy · NA · active not recruiting
- NCT05828368 — DKK-3 rs11544814 and CFH rs10737680 Polymorphism and Protein Levels With Non Surgical Periodontal Therapy in Periodontit · NA · unknown
- NCT05663476 — NSPT On Vitronectin And Fetuin-A Levels In Patients With Periodontitis And Coronary Artery Disease · NA · unknown
- NCT05618743 — NSPT on Calprotectin and Periostin Levels · NA · unknown
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04277390 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Meenakshi Ammal Dental College and Hospital
- Last refreshed: 25 February 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04277390.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing