Who is sponsoring NCT04273919?

NCT04273919 is sponsored by University of Pennsylvania.

What drugs are being tested in NCT04273919?

Interventions in NCT04273919: HTC Vive with Karuna Virtual Reality Program, HTC Vive with Lumen Program.

What condition does NCT04273919 study?

NCT04273919 studies Back Pain Lower Back Chronic.

Is NCT04273919 still recruiting?

NCT04273919 is currently withdrawn. Last updated 16 March 2023.

Last reviewed 2023-03-16 · How we verify

NCT04273919: VR

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Virtual Reality for the Treatment of Chronic Low Back Pain

Withdrawn NA Last updated 16 March 2023

What this trial tests

NA trial testing HTC Vive with Karuna Virtual Reality Program in Back Pain Lower Back Chronic. Withdrawn.

Timeline

1 August 2020

Primary endpoint
1 February 2022

1 February 2022

Quick facts

Lead sponsor	University of Pennsylvania
Phase	NA
Status	Withdrawn
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Start date	1 August 2020
Primary completion	1 February 2022
Estimated completion	1 February 2022
Sites	1 location across United States

Drugs / interventions tested

HTC Vive with Karuna Virtual Reality Program
HTC Vive with Lumen Program

Conditions studied

Back Pain Lower Back Chronic — all drugs for Back Pain Lower Back Chronic →

Sponsor

University of Pennsylvania

Who can join

18 and older, any sex, with Back Pain Lower Back Chronic. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Chronic low back pain is highly prevalent in US adults and is a major cause of missed work days and disability. While several treatment options exist, chronic opioids are commonly used for these conditions even though there are limited data supporting efficacy, and clear evidence of harm associated with chronic opioid administration. Virtual reality has been proposed as a treatment option that may lead to decreased pain and improved physical functioning, while avoiding the harms associated with medication management. This study is intended to obtain preliminary safety and efficacy data to guide the design of a larger clinical trial.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Virtual Reality in the Treatment of Adults with Chronic Low Back Pain: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.
Brea-Gómez B, Torres-Sánchez I, Ortiz-Rubio A, Calvache-Mateo A, et al · · 2021 · cited 57× · PMID 34831562 · DOI 10.3390/ijerph182211806
Adjunct Digital Interventions Improve Opioid-Based Pain Management: Impact of Virtual Reality and Mobile Applications on Patient-Centered Pharmacy Care.
Giravi HY, Biskupiak Z, Tyler LS, Bulaj G. · · 2022 · cited 12× · PMID 35770137 · DOI 10.3389/fdgth.2022.884047

Verify or expand the search:

Other recruiting trials for Back Pain Lower Back Chronic

Currently open trials in the same condition.

NCT07334288 — Retrolaminar Analgesia for LuMbar Surgery · NA · recruiting
NCT06825390 — AuriculoTherapy NeuroImaging · NA · recruiting
NCT06476392 — Melatonin fOr CHronic bAck Pain (The MOCHA Trial) · Phase 3 · active not recruiting
NCT05851196 — The Forgotten Role of Back Muscle Characteristics to Tailor Exercise Therapy for Recurrent Non-specific Low Back Pain · recruiting
NCT05704751 — EVOKE ECAP-Controlled Lead Placement and Programming in Chronic Pain Patients · recruiting

Other University of Pennsylvania trials

Trials by the same sponsor.

NCT06081153 — Mechanistic Clinical Trial of PCSK9 Inhibition for AAA · EARLY_PHASE1 · not yet recruiting
NCT07415772 — Effect of cTBS on Startle and TMS-evoked BOLD · NA · not yet recruiting
NCT07489430 — DaxibotulinumtoxinA for Blepharospasm · Phase 2 · not yet recruiting
NCT07463131 — Negative Income Tax Trial · NA · not yet recruiting
NCT06645769 — Na-Phenylbutyrate VAscular Trial · EARLY_PHASE1 · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04273919 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Pennsylvania
Last refreshed: 16 March 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04273919.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing