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NCT04273022
Effect of Exercise on Biomarkers in SCT
NA trial testing Exercise in Sickle Cell Trait in 12 participants. Completed in 31 December 2024.
31 December 2024
Quick facts
| Lead sponsor | St. Louis University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | single group |
| Masking | single |
| Primary purpose | diagnostic |
| Enrollment | 12 |
| Start date | 27 December 2021 |
| Primary completion | 31 December 2024 |
| Estimated completion | 31 December 2024 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Exercise
Conditions studied
- Sickle Cell Trait — all drugs for Sickle Cell Trait →
Sponsor
St. Louis University
Who can join
Adults 18 to 70, any sex, with Sickle Cell Trait. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study measures the effect of exercise on a variety of biomarkers in blood and urine selected to evaluate the physiological pathways of hemolysis, myolysis, thrombosis, inflammation, and renal function in subjects with sickle cell trait. These pathways have been shown to be associated with adverse events in athletes and warfighters with SCT upon protracted, repeated, strenuous exertion. Changes in biomarkers post-exercise compared to pre-exercise (and compared to healthy controls) suggest activation of the associated pathway(s) which may contribute to exercise-related events in athletes and warfighters and subclinical complications in non-athletes.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT04273022
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Exercise
Trials testing the same drug.
- NCT06231069 — Mixed Exercise Training and Novel Multi-Nutrient Supplementation in Young Adults · NA · withdrawn
- NCT07007858 — Effects of High-Velocity Passive Stretch on Spasticity, Function, and Muscle Structure in Spastic CP Children · NA · enrolling by invitation
- NCT07589725 — Mulligan Mobilization in Lateral Elbow Tendinopathy · NA · not yet recruiting
- NCT07524400 — Effects of Physical Exercise Combined With Transcranial Direct Current Stimulation in Parkinson's Disease · NA · recruiting
- NCT06627569 — Exercise Effects on the Neurobiology Underlying Stress-related Eating Behaviors in Veterans · NA · not yet recruiting
Other recruiting trials for Sickle Cell Trait
Currently open trials in the same condition.
- NCT05292781 — CHOICES3: Sickle Cell Disease Parenting CHOICES · NA · active not recruiting
- NCT07083531 — Bone Loss, Physical Function and Frailty in Older Women With Sickle Cell Trait Sickle Cell Trait · recruiting
- NCT00542230 — Blood Sampling for Research Related to Sickle Cell Disease · recruiting
Other St. Louis University trials
Trials by the same sponsor.
- NCT07024940 — Short-term Effects of Caffeine and a Multi-ingredient Pre-workout on Exercise Performance · NA · recruiting
- NCT06859528 — Step Up to PD: A Community-based Walking Program for People With Parkinson's Disease · NA · recruiting
- NCT04158037 — Don't Go There: A Geospatial mHealth App for Gambling Disorder · NA · withdrawn
- NCT05406310 — Clinical Outcomes of Persistent Atrial Fibrillation Ablation Using Ablation Index-guided Radiofrequency Catheter Ablatio · withdrawn
- NCT05854836 — Preconception Intervention for Incarcerated Women With Substance Use · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04273022 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by St. Louis University
- Last refreshed: 28 January 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04273022.
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