NCT00542230

Blood Sampling for Research Related to Sickle Cell Disease

Recruiting now Last updated 9 March 2026

What this trial tests

trial in Sickle Cell Trait in 250 participants. Currently enrolling.

Timeline

7 November 2007

Quick facts

Lead sponsor	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Status	Recruiting now
Study type	OBSERVATIONAL
Enrollment	250
Start date	7 November 2007
Sites	1 location across United States

Conditions studied

• Sickle Cell Trait — all drugs for Sickle Cell Trait →
• Sickle Cell Disease — all drugs for Sickle Cell Disease →
• Sickle Cell Anemia — all drugs for Sickle Cell Anemia →

Sponsor

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Who can join

Adults 18 to 100, any sex, with Sickle Cell Trait or Sickle Cell Disease. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study will collect representative blood samples from healthy children and adults and from children and adults who have unique red blood cell features that are related to sickle cell disease. Sickle cell disease is a blood disease that limits the ability of red blood cells to carry oxygen throughout the body. The purpose of the study is to collect a variety of blood samples that may then be used to investigate advances and potential new drug treatments for sickle cell disease.

Volunteers must be at least 18 years of old. Samples will be taken both from healthy volunteers and from volunteers who have unique red blood cell features that are related to sickle cell disease. Candidates will be screened with a medical history.

During the study, participants will undergo a one- to two-hour outpatient procedure at the National Institutes of Health Clinical Center. Once researchers have explained the study and obtained the participant s consent, participants will donate 8 cc (approximately 2 teaspoons) of blood.

Because repeat testing helps researchers validate study findings, participants who have the unique red blood cell features mentioned above may also be asked if they are willing to return and donate another 2 cc to 8 cc of blood for additional studies. The amount of blood drawn will not exceed 50 ml with any eight-week period for adults or 7 cc within any six-week period for children.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. Proteomic identification of altered apolipoprotein patterns in pulmonary hypertension and vasculopathy of sickle cell disease.
   Yuditskaya S, Tumblin A, Hoehn GT, Wang G, et al · · 2009 · cited 65× · PMID 19023114 · DOI 10.1182/blood-2008-03-142604
2. Hydroxyurea-induced expression of glutathione peroxidase 1 in red blood cells of individuals with sickle cell anemia.
   Cho CS, Kato GJ, Yang SH, Bae SW, et al · · 2010 · cited 44× · PMID 19951064 · DOI 10.1089/ars.2009.2978