NCT04268615: CS-TRIGGER

Covert Saccade Triggers in Bilateral Vestibular Hypofunction

Completed NA Last updated 2 September 2025

What this trial tests

NA trial testing Covert Saccades and Virtual Reality in Reflex, Abnormal in 32 participants. Completed in 21 March 2022.

Timeline

15 December 2020

Primary endpoint
21 March 2022

21 March 2022

Quick facts

Lead sponsor	Hospices Civils de Lyon
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	non randomized
Design	parallel
Masking	none
Primary purpose	basic science
Enrollment	32
Start date	15 December 2020
Primary completion	21 March 2022
Estimated completion	21 March 2022
Sites	1 location across France

Drugs / interventions tested

• Covert Saccades and Virtual Reality
• Actives versus passives Head Impulses
• Visually guided saccades

Conditions studied

• Reflex, Abnormal — all drugs for Reflex, Abnormal →
• Bilateral Vestibulopathy — all drugs for Bilateral Vestibulopathy →
• Healthy Volunteers — all drugs for Healthy Volunteers →

Sponsor

Hospices Civils de Lyon — full company profile →

Who can join

Adults 18 to 90, any sex, with Reflex, Abnormal or Bilateral Vestibulopathy. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Patients with chronic bilateral vestibular hypofunction may suffer from a visual instability during head movement called oscillopsia. Visual consequence of vestibular deficit can lead to a severe impairment of their quality of life. However, correcting saccades during rapid head movement, called covert-saccades, have been more recently identified. These saccades, which occur during the head movement in patients with vestibular hypofunction, present a very short latency. They could compensate for the lack of vestibular-ocular reflex and greatly decrease oscillopsia and visual impairment. The triggering of these covert-saccade is still not known. They could be of visual origin but the short latency is unusual. The objective of this study is to evaluate the potential role of visual trigger in 12 patients with chronic bilateral areflexia, using different visuo-vestibular conditions. The latency of simple visually guided saccades will also be tested in the group of patients and a group of 12 healthy controls.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Virtual reality set-up for studying vestibular function during head impulse test.
   Desoche C, Verdelet G, Salemme R, Farnè A, et al · · 2023 · cited 4× · PMID 37064179 · DOI 10.3389/fneur.2023.1151515