NCT04255784 is a NA clinical trial of Active iTBS in Major Depressive Disorder, sponsored by Centre for Addiction and Mental Health.

Who is sponsoring NCT04255784?

NCT04255784 is sponsored by Centre for Addiction and Mental Health.

What drugs are being tested in NCT04255784?

Interventions in NCT04255784: Active iTBS, Sham iTBS.

What condition does NCT04255784 study?

NCT04255784 studies Major Depressive Disorder.

Is NCT04255784 still recruiting?

NCT04255784 is currently completed. Last updated 29 January 2025.

Last reviewed 2025-01-29 · How we verify

NCT04255784

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

High Dose Accelerated iTBS for Depression

Completed NA Last updated 29 January 2025

What this trial tests

NA trial testing Active iTBS in Major Depressive Disorder in 228 participants. Completed in 24 January 2025.

Timeline

6 February 2020

Primary endpoint
24 January 2025

24 January 2025

Quick facts

Lead sponsor	Centre for Addiction and Mental Health
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	treatment
Enrollment	228
Start date	6 February 2020
Primary completion	24 January 2025
Estimated completion	24 January 2025
Sites	2 locations across Canada

Drugs / interventions tested

Active iTBS
Sham iTBS

Conditions studied

Major Depressive Disorder — all drugs for Major Depressive Disorder →

Sponsor

Centre for Addiction and Mental Health — full company profile →

Who can join

Adults 18 to 65, any sex, with Major Depressive Disorder. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This trial will compare active intermittent theta burst stimulation (iTBS) rTMS in an accelerated treatment schedule (8 treatment sessions per day for 5 days) to a placebo control. Depression symptom severity will be measured before, during, at end of treatment, 1-week post and 4-weeks post treatment.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

A randomized sham-controlled trial of high-dosage accelerated intermittent theta burst rTMS in major depression: study protocol.
Goodman MS, Vila-Rodriguez F, Barwick M, Burke MJ, et al · · 2024 · cited 5× · PMID 38191370 · DOI 10.1186/s12888-023-05470-9
Extended course accelerated intermittent theta burst stimulation as a substitute for depressed patients needing electroconvulsive therapy.
Goodman MS, Trevizol AP, Konstantinou GN, Boivin-Lafleur D, et al · · 2025 · cited 4× · PMID 39443721 · DOI 10.1038/s41386-024-02007-w

Verify or expand the search:

Other trials of Active iTBS

Trials testing the same drug.

NCT07439367 — Multifocal Theta-Burst Stimulation to Enhance Upper Limb Motor Recovery After Stroke (INSPIRE) · NA · recruiting
NCT07106645 — Intermittent Theta Burst Transcranial Magnetic Stimulation of the Right Parietal Lobe in Anorexia Nervosa · NA · not yet recruiting
NCT06770556 — Transcranial Magnetic Stimulation (TMS) Effects Using Magnetoencephalography (MEG) Study · NA · recruiting
NCT06210100 — aiTBS for NSSI and Suicide in Adolescent Depression · NA · recruiting
NCT05783063 — iTBS for Increased Appetite Induced by Antipsychotics · NA · recruiting

Other recruiting trials for Major Depressive Disorder

Currently open trials in the same condition.

NCT07219394 — Peer-Delivered Behavioral Activation in a CCBHC · NA · recruiting
NCT06705478 — Pramipexole Versus Escitalopram to Treat Major Depressive Disorder (MDD) and Comorbid MDD With Mild Neurocognitive Disor · Phase 2 · recruiting
NCT06749392 — An Individual-specific Synchrony Signature · NA · recruiting
NCT07316803 — Group Intervention for Romantic Relationships in Young Adults With Severe Mental Illness · NA · recruiting
NCT07242105 — Optimizing Brain Excitability in Depression · NA · recruiting

Other Centre for Addiction and Mental Health trials

Trials by the same sponsor.

NCT07211438 — Evaluating the Role of Psilocybin Monitors in Psilocybin Therapy for Treatment Resistant Depression · Phase 2 · not yet recruiting
NCT07146633 — Efficacy of an EMDR App for PTSD and SUD · NA · recruiting
NCT07228923 — Development and Evaluation of a Theory and Evidence-based Intervention to Reduce Hazardous Alcohol Consumption Among Tre · NA · not yet recruiting
NCT07105449 — THC Titration of High-Potency Cannabis Concentrates · NA · not yet recruiting
NCT06928935 — Digital Dialectical Behavioural Therapy (d-DBT) for Youth at Clinical High Risk (CHR) for Psychosis · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04255784 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Centre for Addiction and Mental Health
Last refreshed: 29 January 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04255784.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing