NCT04253587: LABYR

Wayfinding Intervention in High-Fidelity Long-Term Memory

Completed NA Results posted Last updated 27 February 2023

What this trial tests

NA trial testing LabyrinthVR in Long-Term Memory Decline in 50 participants. Completed in 15 December 2021.

Timeline

1 October 2019

Primary endpoint
15 December 2021

15 December 2021

Quick facts

Lead sponsor	University of California, San Francisco
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	basic science
Enrollment	50
Start date	1 October 2019
Primary completion	15 December 2021
Estimated completion	15 December 2021
Sites	1 location across United States

Drugs / interventions tested

• LabyrinthVR
• Placebo Games
• Coherence
• Tablet

Conditions studied

• Long-Term Memory Decline — all drugs for Long-Term Memory Decline →
• Mild Cognitive Impairment — all drugs for Mild Cognitive Impairment →

Sponsor

University of California, San Francisco

Who can join

Adults 62 to 85, any sex, with Long-Term Memory Decline or Mild Cognitive Impairment. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

MDT Change in Mnemonic Discrimination Primary · baseline immediately before and post-assessment immediately after training regimen is completed

Mnemonic discrimination task testing recognition memory for common objects, as reported in scores on a scale of the Lure Discrimination Index ranging from 0.00 to 1.00 where higher values show better performance.

Group	Value	95% CI
LabyrinthVR Trackers	0.09	± 0.03
Placebo Controls	0.01	± 0.03

WALK Change in Recall Primary · baseline immediately before and post-assessment immediately after training regimen is completed

Encoding and test of recent autobiographical long-term memory, as reported in scores on a scale of Percentage of Items Recalled ranging from 0.00 to 1.00 where higher values show better performance.

Group	Value	95% CI
LabyrinthVR Trackers	0.03	± 0.02
Placebo Controls	0.00	± 0.02

Sponsor's own description

Therapeutic treatment is yet available for declining memory, which is an impairment affecting the quality of life for many older adults and patients with cognitive impairment. Cognitive training with an immersive video game promises to drive hippocampal-cortical plasticity and associated gains that can restore memory capability or provide therapeutic treatment for memory deficits.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. Potential Use of Exosomes as Diagnostic Biomarkers and in Targeted Drug Delivery: Progress in Clinical and Preclinical Applications.
   Huda MN, Nafiujjaman M, Deaguero IG, Okonkwo J, et al · · 2021 · cited 160× · PMID 33988964 · DOI 10.1021/acsbiomaterials.1c00217
2. Virtual reality video game improves high-fidelity memory in older adults.
   Wais PE, Arioli M, Anguera-Singla R, Gazzaley A. · · 2021 · cited 36× · PMID 33510315 · DOI 10.1038/s41598-021-82109-3