Who is sponsoring NCT04246827?

NCT04246827 is sponsored by Duke University.

What drugs are being tested in NCT04246827?

Interventions in NCT04246827: Enhanced Lifestyle Weight Management.

What condition does NCT04246827 study?

NCT04246827 studies Rheumatoid Arthritis, Obesity, Pain.

Is NCT04246827 still recruiting?

NCT04246827 is currently completed. Last updated 29 January 2020.

Last reviewed 2020-01-29 · How we verify

NCT04246827: EMBRACE

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Rheumatoid Arthritis Coping Enhancement

Completed NA Last updated 29 January 2020

What this trial tests

NA trial testing Enhanced Lifestyle Weight Management in Rheumatoid Arthritis in 50 participants. Completed in 30 September 2011.

Timeline

7 July 2009

Primary endpoint
30 September 2011

30 September 2011

Quick facts

Lead sponsor	Duke University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	other
Enrollment	50
Start date	7 July 2009
Primary completion	30 September 2011
Estimated completion	30 September 2011
Sites	1 location across United States

Drugs / interventions tested

Enhanced Lifestyle Weight Management

Conditions studied

Rheumatoid Arthritis — all drugs for Rheumatoid Arthritis →
Obesity — all drugs for Obesity →
Pain — all drugs for Pain →

Sponsor

Duke University

Who can join

Adults 18 to 85, any sex, with Rheumatoid Arthritis or Obesity. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study will test an enhanced lifestyle behavioral weight management program that integrates pain coping strategies with a lifestyle intervention that we expect to enhance obese RA patient's ability to cope with pain-related weight challenges. In the proposed study, up to 120 obese (RA-BMI \> 28) rheumatoid arthritis patients will be consented in order to randomly assign 80 patients to one of two conditions: 1) an Enhanced Lifestyle Weight Management protocol or 2) standard care control. Patients randomized to the Enhanced Lifestyle Weight Management condition will participate in a 12-week protocol in which training in coping skills to increase self-efficacy and decrease the impact of RA pain on behavioral (e.g., activity, eating) and psychosocial (e.g., mood, relationships) weight loss factors will be integrated into a lifestyle behavioral weight loss intervention.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Effects of a Weight and Pain Management Program in Patients With Rheumatoid Arthritis With Obesity: A Randomized Controlled Pilot Investigation.
Somers TJ, Blumenthal JA, Dorfman CS, Huffman KM, et al · · 2022 · cited 9× · PMID 34670994 · DOI 10.1097/rhu.0000000000001793

Verify or expand the search:

Other recruiting trials for Rheumatoid Arthritis

Currently open trials in the same condition.

NCT07433335 — A Study to Assess the Safety and Tolerability of SR-878 in Patients With Rheumatoid Arthritis · Phase 1 · recruiting
NCT07491016 — Efficacy and Safety of Telitacicept Combined With Baricitinib for Refractory Rheumatoid Arthritis · recruiting
NCT07171983 — A Study to Evaluate the Safety, Tolerability, and Drug Levels of BMS-986454 in Participants With Rheumatoid Arthritis · Phase 1 · recruiting
NCT07246096 — Exploratory Clinical Study on the Safety and Efficacy of Anti- CD19/BCMA U CAR-T Cell Injection for the Treatment of Rel · EARLY_PHASE1 · recruiting
NCT07363590 — A Clinical Study of MK-1045 in People With Lupus or Rheumatoid Arthritis (MK-1045-004) · Phase 1 · recruiting

Other Duke University trials

Trials by the same sponsor.

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04246827 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Duke University
Last refreshed: 29 January 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04246827.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing