Who is sponsoring NCT04243044?

NCT04243044 is sponsored by Shepherd Center, Atlanta GA.

What drugs are being tested in NCT04243044?

Interventions in NCT04243044: Transcutaneous spinal stimulation.

What condition does NCT04243044 study?

NCT04243044 studies Spinal Cord Injuries.

Is NCT04243044 still recruiting?

NCT04243044 is currently completed. Last updated 7 March 2024.

Last reviewed 2024-03-07 · How we verify

NCT04243044

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Influence of Transcutaneous Spinal Stimulation Intensity on Spasticity After SCI

Completed NA Last updated 7 March 2024

What this trial tests

NA trial testing Transcutaneous spinal stimulation in Spinal Cord Injuries in 21 participants. Completed in 1 December 2023.

Timeline

8 April 2022

Primary endpoint
1 December 2023

1 December 2023

Quick facts

Lead sponsor	Shepherd Center, Atlanta GA
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	single
Primary purpose	treatment
Enrollment	21
Start date	8 April 2022
Primary completion	1 December 2023
Estimated completion	1 December 2023
Sites	1 location across United States

Drugs / interventions tested

Transcutaneous spinal stimulation

Conditions studied

Spinal Cord Injuries — all drugs for Spinal Cord Injuries →

Sponsor

Shepherd Center, Atlanta GA

Who can join

16 and older, any sex, with Spinal Cord Injuries. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Transcutaneous spinal stimulation (TSS) is a form of electrical stimulation delivered over the skin of the spine that may be valuable for reducing spasticity without the side effects of antispasticity medications. The intensity of stimulation, or dose, that promotes the best response is not known. Understanding the response to different intensities of stimulation and how they affect spasticity will help guide rehabilitation for persons with SCI. Therefore, this study aims to identify the effects of TSS as a non-drug intervention for spasticity management.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

Optimizing transcutaneous spinal stimulation: excitability of evoked spinal reflexes is dependent on electrode montage.
Thatcher KL, Nielsen KE, Sandler EB, Daliet OJ, et al · · 2025 · cited 3× · PMID 39762915 · DOI 10.1186/s12984-024-01524-5
Transcutaneous Spinal Stimulation Modulates Spinal Reflex Circuit Excitability in Persons with Spinal Cord Injury.
Sandler EB, Iddings JA, Minassian K, Field-Fote EC. · · 2025 · cited 1× · PMID 41007758 · DOI 10.3390/biomedicines13092195
Immediate Effects of Transcutaneous Spinal Stimulation on Stretch-Induced Spasticity in Persons with Spinal Cord Injury.
Sandler EB, Iddings JA, Field-Fote EC. · · 2025 · PMID 41300207 · DOI 10.3390/brainsci15111201
Optimizing Transcutaneous Spinal Stimulation: Excitability of Evoked Spinal Reflexes is Dependent on Electrode Montage
Thatcher KL, Nielsen KE, Sandler EB, Daliet OJ, et al · · 2024 · DOI 10.21203/rs.3.rs-4719031/v1

Verify or expand the search:

Other trials of Transcutaneous spinal stimulation

Trials testing the same drug.

NCT04043715 — Comparison of Transcutaneous and Epidural Spinal Stimulation for Improving Function · NA · withdrawn
NCT03509558 — Transcutaneous Spinal Stimulation and Exercise for Locomotion · NA · recruiting
NCT03184792 — Transcutaneous Electrical Spinal Stimulation to Restore Upper Extremity Functions in Spinal Cord Injury · NA · completed
NCT03240601 — Spinal Cord Stimulation to Augment Activity Based Therapy · NA · completed

Other recruiting trials for Spinal Cord Injuries

Currently open trials in the same condition.

NCT07109804 — Cuneiform Nucleus (CnF) Deep Brain Stimulation for Gait Facilitation Following Spinal Cord Injury · NA · recruiting
NCT07472985 — Protocol for Rapid Onset of Mobilization in Patients With Traumatic Spinal Cord Injury II (PROMPT-SCI II) Trial · NA · recruiting
NCT07210411 — Acute and Chronic Repercussion of Spinal Cord Stimulation After Spinal Cord Injury · NA · recruiting
NCT07488793 — Remote Ischemic Conditioning for PwSCI · NA · recruiting
NCT07536386 — Self-balancing Personal Exoskeleton for SCI (WIP) · NA · recruiting

Other Shepherd Center, Atlanta GA trials

Trials by the same sponsor.

NCT06214208 — Influence of Spinal Stimulation Frequency on Spasticity, Motor Control, and Pain After Spinal Cord Injury · NA · recruiting
NCT04238013 — Neuromodulation of Ankle Muscles in Persons With SCI · NA · terminated
NCT04777149 — Random Noise Stimulation to Enhance Cortical Drive & Improve Hand Function · NA · completed
NCT06126549 — Comparison of Two Interventions for Caregivers of Patients With Acquired Brain Injury · NA · completed
NCT04130295 — Influence of Wearable Intensive Nerve Stimulation on Spasticity and Function in Persons With Spinal Cord Injury · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04243044 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Shepherd Center, Atlanta GA
Last refreshed: 7 March 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04243044.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing