NCT04234139 is a clinical trial of liver transplant in Liver Diseases, Alcoholic, sponsored by Johns Hopkins University.

Who is sponsoring NCT04234139?

NCT04234139 is sponsored by Johns Hopkins University.

What drugs are being tested in NCT04234139?

Interventions in NCT04234139: liver transplant.

What condition does NCT04234139 study?

NCT04234139 studies Liver Diseases, Alcoholic, Alcohol-Related Disorders, Transplant; Failure, Liver, Transplant; Complication, Rejection, Liver Diseases, Hepatitis, Alcoholic, Alcohol-Induced Disorders.

Is NCT04234139 still recruiting?

NCT04234139 is currently enrolling by invitation. Last updated 16 December 2025.

Last reviewed 2025-12-16 · How we verify

NCT04234139

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Cohort/Ethics Study of Patients With Severe Alcoholic Hepatitis Undergoing Early Liver Transplantation

ENROLLING BY INVITATION Last updated 16 December 2025

What this trial tests

trial testing liver transplant in Liver Diseases, Alcoholic in 300 participants. Enrolling by invitation.

Timeline

1 April 2020

Primary endpoint
31 December 2028

31 December 2029

Quick facts

Lead sponsor	Johns Hopkins University
Status	ENROLLING BY INVITATION
Study type	OBSERVATIONAL
Enrollment	300
Start date	1 April 2020
Primary completion	31 December 2028
Estimated completion	31 December 2029
Sites	1 location across United States

Drugs / interventions tested

liver transplant

Conditions studied

Liver Diseases, Alcoholic — all drugs for Liver Diseases, Alcoholic →
Alcohol-Related Disorders — all drugs for Alcohol-Related Disorders →
Transplant; Failure, Liver — all drugs for Transplant; Failure, Liver →
Transplant; Complication, Rejection — all drugs for Transplant; Complication, Rejection →

Sponsor

Johns Hopkins University

Who can join

18 and older, any sex, with Liver Diseases, Alcoholic or Alcohol-Related Disorders. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of this study is to develop a clinical understanding of early liver transplantation (ELT) for patients with severe alcoholic hepatitis (SAH) and identify the public's opinion regarding this practice.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Reactive oxygen species (ROS)-mediated oxidative stress in chronic liver diseases and its mitigation by medicinal plants.
Sharma P, Nandave M, Nandave D, Yadav S, et al · · 2023 · cited 20× · PMID 38074830

Verify or expand the search:

Other trials of liver transplant

Trials testing the same drug.

NCT04499833 — HepatoPredict Prognostic Tool for the Decision of Liver Transplant in Hepatocellular Carcinoma · NA · recruiting

Other recruiting trials for Liver Diseases, Alcoholic

Currently open trials in the same condition.

NCT06493773 — Alcohol Misuse Treatment to Patients Newly Diagnosed With Alcohol-related Liver Disease: a Randomized Controlled Trial · NA · recruiting
NCT06613698 — A Study to Investigate the Safety and Efficacy of GSK4532990 Compared With Placebo in Adult Participants Aged 18 to 70 Y · Phase 2 · recruiting
NCT03308916 — Screening At-risk Populations for Hepatic Fibrosis With Non-invasive Markers · NA · recruiting

Other Johns Hopkins University trials

Trials by the same sponsor.

NCT06236542 — Tracheostomy Robotics and Cutting-edge Health Education for Airway Safety · NA · not yet recruiting
NCT07532252 — Daridorexant for Alcohol Use Disorder · Phase 2 · not yet recruiting
NCT06687655 — Impact of Exogenous Ketones on Sleep Apnea · Phase 1, PHASE2 · not yet recruiting
NCT07079111 — 3D Printed Occlusal Splints for Intraoperative Use · NA · not yet recruiting
NCT02998502 — The Use of a FDA Cleared, Drug-free, Breathing System for Anxiety and Panic Disorders in Children and Teens · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04234139 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Johns Hopkins University
Last refreshed: 16 December 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04234139.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing