Who is sponsoring NCT04232410?

NCT04232410 is sponsored by University Hospital, Antwerp.

What drugs are being tested in NCT04232410?

Interventions in NCT04232410: Drug induced sleep endoscopy, Measurement of critical closing pressure of the uppper airway.

What condition does NCT04232410 study?

NCT04232410 studies Obstructive Sleep Apnea.

Is NCT04232410 still recruiting?

NCT04232410 is currently completed. Last updated 5 August 2021.

Last reviewed 2021-08-05 · How we verify

NCT04232410: Pcrit-DISE

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Measurement of Critical Closing Pressure (Pcrit) During Drug-Induced Sleep Endoscopy (DISE)

Completed Last updated 5 August 2021

What this trial tests

trial testing Drug induced sleep endoscopy in Obstructive Sleep Apnea in 13 participants. Completed in 1 December 2020.

Timeline

15 January 2020

Primary endpoint
27 October 2020

1 December 2020

Quick facts

Lead sponsor	University Hospital, Antwerp
Status	Completed
Study type	OBSERVATIONAL
Enrollment	13
Start date	15 January 2020
Primary completion	27 October 2020
Estimated completion	1 December 2020
Sites	1 location across Belgium

Drugs / interventions tested

Drug induced sleep endoscopy
Measurement of critical closing pressure of the uppper airway

Conditions studied

Obstructive Sleep Apnea — all drugs for Obstructive Sleep Apnea →

Sponsor

University Hospital, Antwerp

Who can join

18 and older, any sex, with Obstructive Sleep Apnea. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study intends to test the feasibility of measurement of the critical closing pressure (Pcrit) during drug-induced sleep endoscopy (DISE) for use in future studies, which are aimed at finding an alternative method for patient selection and response prediction before implementation of non-CPAP therapies.Twenty patients diagnosed with OSA and eligible for non-CPAP treatments are going to be included into this study and undergo these measurements. Drug-induced sleep endoscopy (DISE) is part of the standard clinical care for OSA patients that are eligible for non-CPAP therapies. We aim to expand this procedure with measurement of Pcrit, oesophageal pressure, airflow, EEG, EOG, respiratory effort, SpO2 and chin EMG during this study.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

The effect of CPAP on the upper airway and ventilatory flow in patients with obstructive sleep apnea.
Van de Perck E, Kazemeini E, Van den Bossche K, Willemen M, et al · · 2023 · cited 7× · PMID 37259138 · DOI 10.1186/s12931-023-02452-z
Critical closing pressure of the pharyngeal airway during routine drug-induced sleep endoscopy: feasibility and protocol.
Kazemeini E, Van de Perck E, Dieltjens M, Willemen M, et al · · 2022 · cited 1× · PMID 35112928 · DOI 10.1152/japplphysiol.00624.2021

Verify or expand the search:

Other trials of Drug induced sleep endoscopy

Trials testing the same drug.

NCT07422402 — Drug-Induced Sleep Endoscopy in Guiding Non-CPAP Therapy in Obstructive Sleep Apnea · NA · completed

Other recruiting trials for Obstructive Sleep Apnea

Currently open trials in the same condition.

NCT07195253 — Oro-myofunctional Characteristics and Obstructive Sleep Apnea in Infants With Down Syndrome · recruiting
NCT07273019 — Tongue Muscular Assessment in Children With Sleep Disordered Breathing · NA · recruiting
NCT07447011 — Glaucoma Respsosne to Lifestyle Corrections in Sleep Apnea · NA · recruiting
NCT07397780 — RPMO2 Oximeter Accuracy During Sleep 1 Trial · active not recruiting
NCT06698809 — Obstructive Sleep Apnea Therapeutic Intervention for REsiDual Sleepiness · NA · recruiting

Other University Hospital, Antwerp trials

Trials by the same sponsor.

NCT07455422 — A Study of Barrett's Esophagus Patients: Optimization of a Risk Model to Better Predict the Development of Cancer Recurr · NA · not yet recruiting
NCT07020715 — A Phase IIa Study of Vitamin D3 Tolerogenic Dendritic Cells (tolDC) for Multiple Sclerosis · Phase 2 · not yet recruiting
NCT07443761 — Patients Undergoing Pancreatic Surgery at the Antwerp University Hospital. · active not recruiting
NCT06372847 — DISE-HNS Effect Study · NA · recruiting
NCT07189091 — CReep and Maintenance flUid Sodium Chloride ADministration rEduction in cRitically Ill adultS · Phase 4 · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04232410 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University Hospital, Antwerp
Last refreshed: 5 August 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04232410.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing