NCT04227223 is a NA clinical trial of biochemical measurements in Pain, sponsored by Medical University of Bialystok.

Who is sponsoring NCT04227223?

NCT04227223 is sponsored by Medical University of Bialystok.

What drugs are being tested in NCT04227223?

Interventions in NCT04227223: biochemical measurements.

What condition does NCT04227223 study?

NCT04227223 studies Pain, Opioids.

Is NCT04227223 still recruiting?

NCT04227223 is currently completed. Last updated 18 February 2021.

Last reviewed 2021-02-18 · How we verify

NCT04227223

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Oxidative Balance in Opioid Therapy

Completed NA Last updated 18 February 2021

What this trial tests

NA trial testing biochemical measurements in Pain in 50 participants. Completed in 15 February 2021.

Timeline

25 September 2019

Primary endpoint
15 February 2021

15 February 2021

Quick facts

Lead sponsor	Medical University of Bialystok
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	non randomized
Design	parallel
Masking	none
Primary purpose	diagnostic
Enrollment	50
Start date	25 September 2019
Primary completion	15 February 2021
Estimated completion	15 February 2021
Sites	1 location across Poland

Drugs / interventions tested

biochemical measurements

Conditions studied

Pain — all drugs for Pain →
Opioids — all drugs for Opioids →

Sponsor

Medical University of Bialystok

Who can join

Adults 18 to 90, any sex, with Pain or Opioids. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The oxidative - antioxidative balance is the crucial mechanism of opioid-induced immunomodulation. Additionally, impairement of cognitive function during opioid therapy is another important side- effect. This phenomenon was clearly described in opioids abuse. This is interesting to evaluate the importance of this subjects in chronic pain patients. The aim of the study was to investigate the oxidative - antioxidative homeostasis and cognitive functions using serum total oxidative capacity (TOC) and total antioxidative capacity (TAC) tests and Brain Derivered Neutrophic Factor (BDNF) in patient with chronic non-cancer pain treated with opioids.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Opioid Therapy and Implications for Oxidative Balance: A Clinical Study of Total Oxidative Capacity (TOC) and Total Antioxidative Capacity (TAC).
Kosciuczuk U, Jakubow P, Tarnowska K, Rynkiewicz-Szczepanska E. · · 2023 · cited 7× · PMID 38202088 · DOI 10.3390/jcm13010082
Plasma Brain-Derived Neurotrophic Factor and Opioid Therapy: Results of Pilot Cross-Sectional Study.
Kosciuczuk U, Jakubow P, Czyzewska J, Knapp P, et al · · 2022 · cited 7× · PMID 36581402 · DOI 10.3121/cmr.2022.1731

Verify or expand the search:

Other trials of biochemical measurements

Trials testing the same drug.

NCT06818045 — Nonsurgical Periodontal Treatment Combined With Anti-TNF-α in Patients With Rheumatoid Arthritis and Periodontitis · NA · completed

Other recruiting trials for Pain

Currently open trials in the same condition.

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Other Medical University of Bialystok trials

Trials by the same sponsor.

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NCT07325552 — iStent Inject Versus Goniotomy With Kahook Dual Blade in Glauocma Treatment · NA · recruiting
NCT07529145 — Cardiopulmonary Exercise Testing in Lung Cancer Patients Before and During Oncological Treatment · recruiting
NCT06855979 — The Impact of Dietary Intervention on Oxidative/antioxidant Markers and Gut Microbiota in Athletes · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04227223 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Medical University of Bialystok
Last refreshed: 18 February 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04227223.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing