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NCT04224532
The Effect of Pneumoperitoneum Timing on Intracranial Pressure in Laparoscopy
NA trial testing Pneumoperitoneum Timing (Before Positioning) in Intracranial Pressure Increase in 79 participants. Completed in 1 March 2020.
1 March 2020
Quick facts
| Lead sponsor | Bagcilar Training and Research Hospital |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | prevention |
| Enrollment | 79 |
| Start date | 8 January 2020 |
| Primary completion | 1 March 2020 |
| Estimated completion | 1 March 2020 |
| Sites | 1 location across Turkey (Türkiye) |
Drugs / interventions tested
- Pneumoperitoneum Timing (Before Positioning)
- Pneumoperitoneum Timing (After Positioning)
Conditions studied
- Intracranial Pressure Increase — all drugs for Intracranial Pressure Increase →
- Pneumoperitoneum — all drugs for Pneumoperitoneum →
Sponsor
Bagcilar Training and Research Hospital
Who can join
Adults 18 to 65, any sex, with Intracranial Pressure Increase or Pneumoperitoneum. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Reverse Trendelenburg position has been shown to slightly reduce the intracranial pressure associated with pneumoperitoneum. However, there are no studies on the effect of the timing of reverse Trendelenburg position on intracranial pressure. This study will monitor the effect of reverse Trendelenburg position before or after pneumoperitoneum on intracranial pressure and regional cerebral oxygen saturation.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Reverse Trendelenburg position applied prior to pneumoperitoneum prevents excessive increase in optic nerve sheath diameter in laparoscopic cholecystectomy: randomized controlled trial.
Demirgan S, Özcan FG, Gemici EK, Güneyli HC, et al · · 2021 · cited 3× · PMID 33089454 · DOI 10.1007/s10877-020-00608-6
Verify or expand the search:
- PubMed search for NCT04224532
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Bagcilar Training and Research Hospital trials
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04224532 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Bagcilar Training and Research Hospital
- Last refreshed: 4 June 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04224532.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing