Last reviewed · How we verify
NCT04221295
The PREPARE Trial: Exercise Before Surgery to Improve Recovery in Older People With Frailty
NA trial testing Exercise Group in Frailty in 850 participants. Participants enrolled and being followed up; not accepting new ones.
5 June 2024
Quick facts
| Lead sponsor | Ottawa Hospital Research Institute |
|---|---|
| Phase | NA |
| Status | Active, enrolled |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 850 |
| Start date | 24 February 2020 |
| Primary completion | 5 June 2024 |
| Estimated completion | 30 May 2025 |
| Sites | 1 location across Canada |
Drugs / interventions tested
- Exercise Group
Conditions studied
- Frailty — all drugs for Frailty →
- Surgery--Complications — all drugs for Surgery--Complications →
- Disability Physical — all drugs for Disability Physical →
Sponsor
Ottawa Hospital Research Institute
Who can join
60 and older, any sex, with Frailty or Surgery--Complications. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study evaluates whether participating in a home-based exercise program leads to lower levels of complication rates and patient-reported disability after surgery. Half of the participants will be randomized into the exercise group, while the other half will be randomized into the control group.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
PREPARE trial: a protocol for a multicentre randomised trial of frailty-focused preoperative exercise to decrease postoperative complication rates and disability scores.
McIsaac DI, Fergusson DA, Khadaroo R, Meliambro A, et al · · 2022 · cited 8× · PMID 35940835 · DOI 10.1136/bmjopen-2022-064165 -
Can statin preventative treatment inform geroscience-guided therapeutics?
Guaraldi G, Erlandson KM, Milic J, Landay AL, et al · · 2023 · cited 5× · PMID 37830430 · DOI 10.1111/acel.13998 -
Home-Based Prehabilitation for Older Surgical Patients With Frailty: A Randomized Clinical Trial.
McIsaac DI, Lee S, Fergusson D, Gillis C, et al · · 2026 · PMID 41335421 · DOI 10.1001/jamasurg.2025.5288
Verify or expand the search:
- PubMed search for NCT04221295
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Exercise Group
Trials testing the same drug.
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- NCT07016061 — Acute Effects of Motor Imagery and Action Observation in the Elderly: Single-Blind Randomized Controlled Trial · NA · not yet recruiting
- NCT06913439 — Fin Wax Bath Therapy in Patients With Post-traumatic Stiffness of Knee Joint: A Randomized Controlled Trial · NA · active not recruiting
- NCT06274606 — Exercise Training Study Before Bariatric Surgery · NA · withdrawn
- NCT06374004 — The Effect of Thoracic Mobilization in Individuals With Subacromial Pain Syndrome · NA · completed
Other recruiting trials for Frailty
Currently open trials in the same condition.
- NCT07481188 — Frailty and Nottingham Hip Fracture Score for Predicting 90-Day Mortality After Hip Fracture Surgery · recruiting
- NCT07519603 — Frailty in Older Adults With Chronic Obstructive Pulmonary Disease (COPD) and Outcomes of the VIVIFRAIL Program · NA · recruiting
- NCT07144527 — Nicotinamide Mononucleotide Supplementation for Exercise Tolerance Improvement in Healthy Older Adults · NA · recruiting
- NCT07392944 — Multicomponent Exercise Program on Physical Function, Cognition and Falls Risk Among Older Adults Living in Nursing Home · NA · recruiting
- NCT07475767 — Ultrasound Indicators of Nutritional Status and Treatment Outcomes in Surgical Patients in the Intensive Care Unit · recruiting
Other Ottawa Hospital Research Institute trials
Trials by the same sponsor.
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- NCT07171567 — Vacuum Therapy for the Treatment of Penile Numbness/Sensory Changes · EARLY_PHASE1 · recruiting
- NCT07058025 — Mesenchymal Stromal Cell Therapy to Prevent Bronchopulmonary Dysplasia in Extreme Preterm Infants · Phase 2 · not yet recruiting
- NCT07177833 — Title Fractioned CO2 Laser in the Treatment of Chronic Phase Peyronie's Disease · Phase 1 · recruiting
- NCT06929767 — Do Blood Tests Help to Decide Which Patients With Flares of Chronic Obstructive Pulmonary Disease (COPD) Need Antibiotic · Phase 4 · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04221295 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Ottawa Hospital Research Institute
- Last refreshed: 27 August 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04221295.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing