Who is sponsoring NCT04218760?

NCT04218760 is sponsored by Danish Headache Center.

What condition does NCT04218760 study?

NCT04218760 studies Headache, Healthy.

Is NCT04218760 still recruiting?

NCT04218760 is currently completed. Last updated 25 March 2021.

Last reviewed 2021-03-25 · How we verify

NCT04218760

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Multiomics After Headache Provocation of People Who Are Unable to Have Headache

Completed NA Last updated 25 March 2021

What this trial tests

NA trial testing Isosorbide Mononitrate 60 MG Extended Release Oral Tablet [Imdur] in Headache in 58 participants. Completed in 12 March 2020.

Timeline

10 October 2019

Primary endpoint
12 March 2020

12 March 2020

Quick facts

Lead sponsor	Danish Headache Center
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	other
Enrollment	58
Start date	10 October 2019
Primary completion	12 March 2020
Estimated completion	12 March 2020
Sites	1 location across Denmark

Drugs / interventions tested

Isosorbide Mononitrate 60 MG Extended Release Oral Tablet [Imdur] — full drug profile →
Blood sample — full drug profile →

Conditions studied

Headache — all drugs for Headache →
Healthy — all drugs for Healthy →

Sponsor

Danish Headache Center — full company profile →

Who can join

Adults 18 to 70, male only, with Headache or Healthy. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Headaches are extremely common illnesses with a combined lifetime prevalence of 90-99% in Europe. Despite this high prevalence, there are persons who have never, in their whole life, encountered a headache. The aim of the study is to identify factors that protect against headache by studying multiomics in people who never have had a headache (headache resistant) versus non-resistant controls. The investigators will measure multiomic changes (transcriptomics and metabolomics) after headache provocation with isosorbide mononitrate. 3 blood samples, two for RNA and one for metabolomics are taken right before administration of isosorbide mononitrate, 3 hours after administration of isosorbide mononitrate and again 5 hours after administration of isosorbide mononitrate. The investigators hope to contribute with novelty to the current understanding of headache pathophysiology and development of more efficient treatment of headache.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.

Verify or expand the search:

Other recruiting trials for Headache

Currently open trials in the same condition.

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NCT06225817 — Placebo Impacts Sleep and Pain Modulation in Chronic Pain · NA · recruiting
NCT06310200 — Sphenopalatine Ganglion Block and Cold Induced Headaches · Phase 1 · active not recruiting
NCT07404956 — THE EFFECT OF SURGICAL MASK AND N95 MASK USE ON SURGICAL SMOKE IN OPERATING ROOM NURSES · NA · recruiting

Other Danish Headache Center trials

Trials by the same sponsor.

NCT07451769 — Selective Activation of the Adrenomedullin Receptors in Migraine · NA · not yet recruiting
NCT07342296 — Induction of Migraine Attacks With Aura Using Pituitary Adenylate Cyclase Activating Polypeptide-38 · NA · not yet recruiting
NCT07059546 — Hypersensitivity to Adrenomedullin in Post-Traumatic Headache · NA · recruiting
NCT07021859 — Induction of Migraine Attacks With Aura Using Calcitonin Gene-Related Peptide · NA · recruiting
NCT06959004 — Substance P-Induced Migraine Attacks Without Aura · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04218760 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Danish Headache Center
Last refreshed: 25 March 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04218760.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing