NCT04218591 is a NA clinical trial of PRP in Thumb Osteoarthritis, sponsored by Karolinska Institutet.

Who is sponsoring NCT04218591?

NCT04218591 is sponsored by Karolinska Institutet.

What drugs are being tested in NCT04218591?

Interventions in NCT04218591: PRP, Placebo.

What condition does NCT04218591 study?

NCT04218591 studies Thumb Osteoarthritis.

Is NCT04218591 still recruiting?

NCT04218591 is currently completed. Last updated 19 January 2024.

Last reviewed 2024-01-19 · How we verify

NCT04218591

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

A Study on the Effect of Platelet Rich Plasma (PRP) on Osteoarthritis in the Thumb Base

Completed NA Last updated 19 January 2024

What this trial tests

NA trial testing PRP in Thumb Osteoarthritis in 90 participants. Completed in 31 December 2023.

Timeline

24 February 2020

Primary endpoint
31 December 2023

31 December 2023

Quick facts

Lead sponsor	Karolinska Institutet
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	90
Start date	24 February 2020
Primary completion	31 December 2023
Estimated completion	31 December 2023
Sites	1 location across Sweden

Drugs / interventions tested

PRP — full drug profile →
Placebo

Conditions studied

Thumb Osteoarthritis — all drugs for Thumb Osteoarthritis →

Sponsor

Karolinska Institutet

Who can join

Eligibility, any sex, with Thumb Osteoarthritis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Randomized comparison between Platelet Rich Plasma (PRP) and placebo (Saline) for thumb base.osteoarthritis.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

New Trends in Injection-Based Therapy for Thumb-Base Osteoarthritis: Where Are We and where Are We Going?
Tenti S, Cheleschi S, Mondanelli N, Giannotti S, et al · · 2021 · cited 12× · PMID 33927620 · DOI 10.3389/fphar.2021.637904
Platelet-Rich Plasma Injection for Painful Trapeziometacarpal Osteoarthritis: A Double-Blind, Randomized, Placebo-Controlled Trial.
Evans K, von Kieseritzky J, Stenseth J, Wilcke M. · · 2025 · PMID 40487141 · DOI 10.2106/jbjs.oa.25.00027

Verify or expand the search:

Other trials of PRP

Trials testing the same drug.

NCT07453953 — A Comparison of Clinical Efficacy of Mytocel MSK With AMT and PRP Injections in Patients With Knee Osteoarthritis · EARLY_PHASE1 · not yet recruiting
NCT07565844 — Intradermal Exosomes, Platelet-Rich Plasma, and Steroids for Post-Herpetic Neuralgia · NA · recruiting
NCT06384859 — Effectiveness of Extracorporeal Shockwave Therapy Combined With Platelet-rich Plasma in the Treatment of Chronic Inserti · Phase 4 · not yet recruiting
NCT06339645 — Intravesical Platelet-rich Plasma Injection in Patients With Interstitial Cystitis/Bladder-A Retrospective Study · unknown
NCT06332352 — Intra-articular Platelet-Rich Plasma for Acetabular Labral Tears · NA · completed

Other recruiting trials for Thumb Osteoarthritis

Currently open trials in the same condition.

NCT07566507 — High-Energy Laser in the Conservative Treatment of Rhizarthrosis · NA · recruiting
NCT05992883 — NSAID Injection Versus Corticosteroid Injection for Basilar Thumb Arthritis · Phase 3 · recruiting
NCT04828954 — Variable Immobilization Protocol for Arthroplasty of the Carpometacarpal Joint of the Thumb · NA · recruiting
NCT04210687 — Trapeziectomy vs. Trapeziometacarpal Limited Excision for Thumb Base Osteoarthritis · NA · active not recruiting

Other Karolinska Institutet trials

Trials by the same sponsor.

NCT06359262 — Evaluating the Hope@School Prevention Program · NA · not yet recruiting
NCT07289490 — Bilateral vs Unilateral Inguinal Hernia Repairs With an Asymptomatic Inguinal Hernia in Bilateral Hernias · NA · not yet recruiting
NCT06894264 — Emotion Processing and Regulation in People With Intellectual Disability · NA · not yet recruiting
NCT07494266 — Safety of a Healthy Plant-based Diet With Higher Potassium Content, Compared to a Healthy Plant-based Diet With Limited · NA · not yet recruiting
NCT07442032 — Cardiovascular Phenotypes in Sepsis · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04218591 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Karolinska Institutet
Last refreshed: 19 January 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04218591.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing