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NCT04214106
Thiamine Administration and Prevalence of Delirium in the Intensive Care Unit: A Before-after Study
trial testing intravenous Thiamine in Delirium in 1,000 participants. Completed in 1 January 2021.
1 December 2020
Quick facts
| Lead sponsor | Meir Medical Center |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 1,000 |
| Start date | 19 February 2020 |
| Primary completion | 1 December 2020 |
| Estimated completion | 1 January 2021 |
| Sites | 1 location across Israel |
Drugs / interventions tested
- intravenous Thiamine — full drug profile →
Conditions studied
- Delirium — all drugs for Delirium →
Sponsor
Meir Medical Center
Who can join
Adults 18 to 99, any sex, with Delirium. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Delirium is a very common condition among ICU-admitted patients, and its prevalence is estimated between 30-40%. Delirium is associated with increased morbidity and mortality and future cognitive decline, along with increased ventilation-dependency and other complications. There are multiple risk factors for delirium, including deficiencies of micronutrients. Thiamine deficiency is associated with specific neurological syndromes, including Wernicke and Korsakoff syndromes and Delirium Tremens. Several studies demonstrated significant thiamine deficiency among ICU-admitted patients (prevalence of 30-70%) without known risk factors, such as alcohol dependency. Thiamine deficiency may cause delirium in those patients. Intravenous thiamine had been safely used for decades, for several indications. Lately, thiamine has been advocated for therapy in patients with septic shock, and its use in intensive care units has increased worldwide. Since 2016, thiamine has been routinely administered in our intensive care unit. Considering the theoretical association between thiamine deficiency and ICU-related delirium, the investigators aim to investigate whether the routine use of thiamine has been associated with decreased prevalence of delirium among ICU patients when compared to the pre-routine thiamine administration era.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Delirium in Critical Illness Patients and the Potential Role of Thiamine Therapy in Prevention and Treatment: Findings from a Scoping Review with Implications for Evidence-Based Practice.
Lange S, Mędrzycka-Dąbrowska W, Friganovic A, Oomen B, et al · · 2021 · cited 8× · PMID 34444556 · DOI 10.3390/ijerph18168809
Verify or expand the search:
- PubMed search for NCT04214106
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Delirium
Currently open trials in the same condition.
- NCT07348471 — Fecal Microbiota Transplantation for the Treatment of ICU Delirium · NA · recruiting
- NCT06969287 — Mitigating Delirium With Fluvoxamine Treatment for Non-Cardiac Surgery · Phase 3 · recruiting
- NCT07369258 — Clinical Application of Listening to Music to Prevent Delirium in the Intensive Care Unit · NA · recruiting
- NCT07488468 — Quality Improvement Project to Reduce Preoperative Fasting Times Before Elective Procedures · recruiting
- NCT07136207 — Development and Validation of Delirium Recognition Using Computer Vision in Neuro-critical Patients · recruiting
Other Meir Medical Center trials
Trials by the same sponsor.
- NCT07256886 — Validation of the iCVS Model in Patients Admitted to the Intensive Care Unit · not yet recruiting
- NCT07315477 — Characteristics of Patients Intubated for Airway Protection in the Intensive Care Unit and Timing of Tracheostomy · not yet recruiting
- NCT07183410 — Impact of Blood Cultures Drawn From Arterial Lines on the Incidence of Contamination, Detection of Bacteremia, and Blood · not yet recruiting
- NCT07256860 — Influence of Chest X-ray vs. Chest CT Scan on the Management of ICU Patients With Respiratory Failure · not yet recruiting
- NCT05784350 — Preoperative Point of Care Ultrasound Guided Fluid Optimization and Intravenous Ondansetron to Prevent General Anesthesi · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04214106 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Meir Medical Center
- Last refreshed: 24 February 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04214106.
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