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NCT04212182
The Physiological Effect of High Flow Oxygen Therapy
NA trial testing HFNC in High-flow Nasal Cannula in 10 participants. Status unknown.
1 July 2020
Quick facts
| Lead sponsor | The First Affiliated Hospital of Guangzhou Medical University |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 10 |
| Start date | 27 December 2019 |
| Primary completion | 1 July 2020 |
| Estimated completion | 1 July 2020 |
| Sites | 1 location across China |
Drugs / interventions tested
- HFNC
- NPPV
Conditions studied
- High-flow Nasal Cannula — all drugs for High-flow Nasal Cannula →
- Non-invasive Positive Pressure Ventilation — all drugs for Non-invasive Positive Pressure Ventilation →
- Acute Exacerbation of Chronic Obstructive Pulmonary Disease — all drugs for Acute Exacerbation of Chronic Obstructive Pulmonary Disease →
Sponsor
The First Affiliated Hospital of Guangzhou Medical University
Who can join
Adults 18 to 80, any sex, with High-flow Nasal Cannula or Non-invasive Positive Pressure Ventilation. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Although non-invasive positive pressure ventilation (NPPV) shows the good curative effect of treating the patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD), some patients do not tolerate NPPV or do not benefit from it. High-flow nasal cannula (HFNC) is well tolerated and may be used to patients with AECOPD who are intolerant to NPPV treatment. This study is to evaluate the physiological effect of HFNC and compare it with NPPV.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Efficiency of neural respiratory drive changes during non-invasive ventilation and high-flow nasal cannula oxygen therapy in AECOPD patients with acute hypercapnic respiratory failure: A randomised cross-over study.
Guan L, Xu J, He Z, Zha S, et al · · 2026 · PMID 41788481 · DOI 10.1016/j.aicoj.2025.100019
Verify or expand the search:
- PubMed search for NCT04212182
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of HFNC
Trials testing the same drug.
- NCT05962073 — Comparison Physiological Effects According to Preoxygenation Method Using EIT · NA · withdrawn
- NCT04693403 — The Acute Respiratory Intervention StudiEs in Africa (ARISE-AFRICA) Study · NA · completed
- NCT05425836 — HFNC Versus SOT During EBUS · NA · completed
- NCT05548309 — HFNC Versus Oxygen Face Mask on Postoperative Pulmonery Complications · NA · completed
- NCT05708287 — The Physiologic Effect of the Flow Generated by High Flow Nasal Cannula in Mild Respiratory Failure · NA · completed
Other recruiting trials for High-flow Nasal Cannula
Currently open trials in the same condition.
- NCT06425406 — Application of HFNC for the Prevention of Hypoxemia During Perioperative Anesthetic-induced Intubation in Children: A Ra · NA · recruiting
- NCT06879600 — High-Flow Nasal Oxygen for Preoxygenation in Emergency Surgery Patients With Full Stomachs · NA · recruiting
- NCT06582459 — Efficacy and Safety of High-Flow Nasal Cannula Versus Noninvasive Ventilation for Pulmonary Arterial Hypertension-Associ · active not recruiting
- NCT05526534 — A RCT on the Preventive Effect of HFNC on Postoperative Pulmonary Complications in Patients With Gynecologic Neoplasms · NA · recruiting
- NCT06375538 — Ultrasound Evaluations of Diaphragm and Intercostal Muscle to Predict the Failure of High-Flow Nasal Cannula Therapy · recruiting
Other The First Affiliated Hospital of Guangzhou Medical University trials
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04212182 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by The First Affiliated Hospital of Guangzhou Medical University
- Last refreshed: 30 December 2019
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04212182.
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