NCT04209127 (ADENOMIC) is a NA clinical trial of Microwave treatment via needle antenna in Adenomyosis, sponsored by Karolinska Institutet.

Who is sponsoring NCT04209127?

NCT04209127 is sponsored by Karolinska Institutet.

What drugs are being tested in NCT04209127?

Interventions in NCT04209127: Microwave treatment via needle antenna, Embolization of uterine artery or branches thereof (routine treatment where polyvinyl alcohol particles are released into the predefined bloodstream).

What condition does NCT04209127 study?

NCT04209127 studies Adenomyosis.

Is NCT04209127 still recruiting?

NCT04209127 is currently recruiting now. Last updated 20 November 2024.

Last reviewed 2024-11-20 · How we verify

NCT04209127: ADENOMIC

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Comparing Efficacy of Microwave Vs Embolization Treatment for Adenomyosis

Recruiting now NA Last updated 20 November 2024

What this trial tests

NA trial testing Microwave treatment via needle antenna in Adenomyosis in 70 participants. Currently enrolling.

Timeline

16 September 2020

Primary endpoint
30 June 2026

30 June 2026

Quick facts

Lead sponsor	Karolinska Institutet
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	70
Start date	16 September 2020
Primary completion	30 June 2026
Estimated completion	30 June 2026
Sites	1 location across Sweden

Drugs / interventions tested

Microwave treatment via needle antenna
Embolization of uterine artery or branches thereof (routine treatment where polyvinyl alcohol particles are released into the predefined bloodstream)

Conditions studied

Adenomyosis — all drugs for Adenomyosis →

Sponsor

Karolinska Institutet

Who can join

Adults 30 to 55, female only, with Adenomyosis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Single blinded randomized controlled study of symptom improvement after uterine artery embolization (UAE) versus ultrasound guided percutaneous/transvaginal microwave ablation, evaluated by validated questionnaires. Adenomyosis is a benign condition causing pain and bleeding disorders in many women. Hysterectomy has historically been the golden standard for treatment as well as (postoperatively) diagnosis of the disease. In accordance with refined diagnostic tools such as ultrasound and/or MRI, minimally invasive treatments for adenomyosis are being explored. We plan to compare two minimally invasive techniques: embolization of the uterine artery (a commonly used procedure) and microwave ablation of adenomyotic tissue (previously only in clinical use in China).

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Symptom improvement in adenomyosis patients after ultrasound guided microwave ablation or uterine artery embolization, A randomized controlled pilot study.
Jonsdottir G, Lantz E, Beermann M, Paschou M, et al · · 2026 · PMID 41801952 · DOI 10.1371/journal.pone.0343949

Verify or expand the search:

Other recruiting trials for Adenomyosis

Currently open trials in the same condition.

NCT07455721 — Central Sensitization in Women With Adenomyosis: Prevalence, Risk Factors, and Therapeutic Failure · active not recruiting
NCT07486622 — Transvaginal Electromechanical Fragmentation and Removal of Large Uterus in a Sealed Bag: The First Group of Clinical St · active not recruiting
NCT06572852 — Next-Generation Endometriosis Diagnostics Through Comprehensive Multi-Dimensional Analysis · recruiting
NCT06364592 — Electroacupuncture for Dysmenorrhea Secondary to Adenomyosis · NA · recruiting
NCT06604091 — Cohort Profile：The Shandong Adenomyosis Cohort of Population Undergoing Reproductive Technology (SAart) · active not recruiting

Other Karolinska Institutet trials

Trials by the same sponsor.

NCT06359262 — Evaluating the Hope@School Prevention Program · NA · not yet recruiting
NCT07289490 — Bilateral vs Unilateral Inguinal Hernia Repairs With an Asymptomatic Inguinal Hernia in Bilateral Hernias · NA · not yet recruiting
NCT06894264 — Emotion Processing and Regulation in People With Intellectual Disability · NA · not yet recruiting
NCT07494266 — Safety of a Healthy Plant-based Diet With Higher Potassium Content, Compared to a Healthy Plant-based Diet With Limited · NA · not yet recruiting
NCT07442032 — Cardiovascular Phenotypes in Sepsis · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04209127 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Karolinska Institutet
Last refreshed: 20 November 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04209127.

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