NCT04205942 is a NA clinical trial of Argon Plasma Jet in Diabetic Foot, sponsored by Ruhr University of Bochum.

Who is sponsoring NCT04205942?

NCT04205942 is sponsored by Ruhr University of Bochum.

What drugs are being tested in NCT04205942?

Interventions in NCT04205942: Argon Plasma Jet, Placebo.

What condition does NCT04205942 study?

NCT04205942 studies Diabetic Foot.

Is NCT04205942 still recruiting?

NCT04205942 is currently status unknown. Last updated 29 March 2023.

Last reviewed 2023-03-29 · How we verify

NCT04205942

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Cold Plasma Therapy for Acceleration of Wound Healing in Diabetic Foot

Status unknown NA Last updated 29 March 2023

What this trial tests

NA trial testing Argon Plasma Jet in Diabetic Foot in 65 participants. Status unknown.

Timeline

17 August 2016

Primary endpoint
20 April 2019

30 April 2024

Quick facts

Lead sponsor	Ruhr University of Bochum
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	65
Start date	17 August 2016
Primary completion	20 April 2019
Estimated completion	30 April 2024

Drugs / interventions tested

Argon Plasma Jet
Placebo

Conditions studied

Diabetic Foot — all drugs for Diabetic Foot →

Sponsor

Ruhr University of Bochum

Who can join

Adults 18 to 80, any sex, with Diabetic Foot. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Diabetic foot is a common complication of diabetes mellitus and requires specialized treatment. Wounds are characterized by persistent infection and chronic inflammatory processes, impeding well directed matrix remodelling and wound closure. Cold plasma applications have demonstrated beneficial effects on wound healing in several case reports. The investigator-initiated "Kaltplasma Wund (KPW)-Trial" was performed to prove beneficial effects of cold plasma in wound healing in a prospective, placebo-controlled, randomized bi-center study.

Publications & conference data

7 peer-reviewed publications reference this trial (live from Europe PMC):

Effect of Cold Atmospheric Plasma Therapy vs Standard Therapy Placebo on Wound Healing in Patients With Diabetic Foot Ulcers: A Randomized Clinical Trial.
Stratmann B, Costea TC, Nolte C, Hiller J, et al · · 2020 · cited 144× · PMID 32672829 · DOI 10.1001/jamanetworkopen.2020.10411
Enhanced growth factor expression in chronic diabetic wounds treated by cold atmospheric plasma.
Hiller J, Stratmann B, Timm J, Costea TC, et al · · 2022 · cited 24× · PMID 35007358 · DOI 10.1111/dme.14787
57<sup>th</sup> EASD Annual Meeting of the European Association for the Study of Diabetes.
· 2021 · cited 11× · PMID 34468792 · DOI 10.1007/s00125-021-05519-y
56<sup>th</sup> EASD Annual Meeting of the European Association for the Study of Diabetes : 21-25 September 2020.
· 2020 · cited 9× · PMID 32840677 · DOI 10.1007/s00125-020-05221-5
Free Radicals in Health and Disease.
Dai X, Huang Z, Lyu R. · · 2025 · cited 1× · PMID 40989573 · DOI 10.1002/mco2.70396
Reactive oxygen species in health and disease.
Ren Y, Li J, Dai X. · · 2026 · PMID 41824175 · DOI 10.1186/s43556-026-00419-2
Cold atmospheric plasma is a promising strategy for treating diabetic retinopathy.
Dai X, Cui W, Xi M. · · 2025 · PMID 41257900 · DOI 10.1186/s12967-025-06962-w

Verify or expand the search:

Other recruiting trials for Diabetic Foot

Currently open trials in the same condition.

NCT06487780 — Evaluating a Lifestyle Intervention to Prevent Recurrence of Diabetic Foot Ulcers · NA · recruiting
NCT06674980 — Clinical Trial Assessing Human Placental Membrane Products and Standard of Care Versus Standard of Care in Nonhealing DF · NA · recruiting
NCT06760416 — Online Diabetic Foot Support Program- Care Kit · NA · active not recruiting
NCT06552910 — Analyzing Anesthetic Techniques in Diabetic Foot Amputation · recruiting
NCT06526936 — The Effect of Foot Care Training Given to Diabetic Hemodialysis Patients on Foot Care Behavior · NA · recruiting

Other Ruhr University of Bochum trials

Trials by the same sponsor.

NCT07432945 — In Vivo Exposure vs. Videochat-Based Vicarious Exposure · NA · recruiting
NCT06255821 — The Effect of Time on Generalization of Exposure-based Benefit · NA · completed
NCT05824884 — Self-efficacy Enhancement in a Virtual Reality Training for Fear of Heights · NA · recruiting
NCT05798078 — The Relationship Between Social Anxiety and Anxious Thinking Styles · NA · completed
NCT05780203 — CBM in the Context of Exposure for Acrophobia · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04205942 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Ruhr University of Bochum
Last refreshed: 29 March 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04205942.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing