NCT04183348: EVA

Evaluation of the Effect of a Visio-Hearing Training Protocol on Spatial Hearing in Subjects With Hearing Loss

Completed NA Last updated 3 September 2025

What this trial tests

NA trial testing Training Protocol n°1 first at Visit 1, then, Training Protocol n°2 at Visit 2 in Cochlear Nerve Deafness in 79 participants. Completed in 23 May 2022.

Timeline

6 July 2020

Primary endpoint
23 May 2022

23 May 2022

Quick facts

Lead sponsor	Hospices Civils de Lyon
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	none
Primary purpose	other
Enrollment	79
Start date	6 July 2020
Primary completion	23 May 2022
Estimated completion	23 May 2022
Sites	2 locations across France

Drugs / interventions tested

• Training Protocol n°1 first at Visit 1, then, Training Protocol n°2 at Visit 2
• Training Protocol n°2 first at Visit 1, then, Training Protocol n°1 at Visit 2

Conditions studied

• Cochlear Nerve Deafness — all drugs for Cochlear Nerve Deafness →
• Cochlear Diseases — all drugs for Cochlear Diseases →
• Cochlear Hearing Loss — all drugs for Cochlear Hearing Loss →
• Hearing Loss — all drugs for Hearing Loss →

Sponsor

Hospices Civils de Lyon — full company profile →

Who can join

Adults 18 to 65, any sex, with Cochlear Nerve Deafness or Cochlear Diseases. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

We recently developed a new Neuro-immersion system based on virtual reality and 3D (dimension) motion tracking. This tool makes it possible to evaluate and record the spatial localization performance of sounds and to highlight localization deficits in the three dimensions of space in deaf patients. Unfortunately, there is currently no suitable support to compensate for these localization deficits. However, the discomfort felt by the patients is clearly verbalized.

Thanks to the new virtual reality system, we are now able to develop a training protocol based on spatial sound localization tasks.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

1. Adapting to altered auditory cues: Generalization from manual reaching to head pointing.
   Valzolgher C, Todeschini M, Verdelet G, Gatel J, et al · · 2022 · cited 16× · PMID 35421095 · DOI 10.1371/journal.pone.0263509
2. Audiovisual Training in Virtual Reality Improves Auditory Spatial Adaptation in Unilateral Hearing Loss Patients.
   Alzaher M, Valzolgher C, Verdelet G, Pavani F, et al · · 2023 · cited 12× · PMID 36983357 · DOI 10.3390/jcm12062357
3. Training spatial hearing in unilateral cochlear implant users through reaching to sounds in virtual reality.
   Valzolgher C, Bouzaid S, Grenouillet S, Gatel J, et al · · 2023 · cited 6× · PMID 36905419 · DOI 10.1007/s00405-023-07886-1
4. Capturing Visual Attention With Perturbed Auditory Spatial Cues.
   Valzolgher C, Alzaher M, Gaveau V, Coudert A, et al · · 2023 · PMID 37611181 · DOI 10.1177/23312165231182289