NCT04178096

Using Data-Driven Implementation Strategies to Improve the Quality of Cirrhosis Care

Completed NA Results posted Last updated 1 April 2025

What this trial tests

NA trial testing Quality Improvement Intervention in Cirrhosis, Liver in 12 participants. Completed in 31 December 2023.

Timeline

18 September 2020

Primary endpoint
31 December 2023

31 December 2023

Quick facts

Lead sponsor	VA Office of Research and Development
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	health services research
Enrollment	12
Start date	18 September 2020
Primary completion	31 December 2023
Estimated completion	31 December 2023
Sites	1 location across United States

Drugs / interventions tested

• Quality Improvement Intervention

Conditions studied

• Cirrhosis, Liver — all drugs for Cirrhosis, Liver →

Sponsor

VA Office of Research and Development — full company profile →

Who can join

18 and older, any sex, with Cirrhosis, Liver. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Hepatocellular Carcinoma Screening Primary · 6 months after the previous screening.

Active patients, or those with outpatient or prescription activity within the last eighteen months, with a diagnosis of cirrhosis should have abdominal imaging every 6 months. Hepatocellular carcinoma (HCC) and Post-transplant patients are not included. This measure is being assessed by comparing the patients that have had imaging for liver cancer screening in the last eight months to those that have not.

Group	Value	95% CI
Quality Improvement Intervention	1.61	1.54 – 1.69

Sponsor's own description

This Veteran Affairs (VA) Quality Improvement project aims to understand which data-driven implementation strategies promote evidence based practices that improve high-quality care for Veterans with cirrhosis.

Publications & conference data

5 peer-reviewed publications reference this trial (live from Europe PMC):

1. Getting to implementation: a protocol for a Hybrid III stepped wedge cluster randomized evaluation of using data-driven implementation strategies to improve cirrhosis care for Veterans.
   Rogal SS, Yakovchenko V, Morgan T, Bajaj JS, et al · · 2020 · cited 24× · PMID 33087156 · DOI 10.1186/s13012-020-01050-7
2. Getting to implementation: Adaptation of an implementation playbook.
   Yakovchenko V, Rogal SS, Goodrich DE, Lamorte C, et al · · 2022 · cited 13× · PMID 36684876 · DOI 10.3389/fpubh.2022.980958
3. The "good enough" facilitator: elucidating the role of working alliance in the mechanism of facilitation.
   Yakovchenko V, Merante M, Chinman MJ, Neely B, et al · · 2025 · cited 4× · PMID 40001234 · DOI 10.1186/s43058-025-00705-0
4. Getting to Implementation: applying data-driven implementation strategies to improve guideline concordant surveillance for hepatocellular carcinoma.
   Yakovchenko V, Kang C, Neely B, Lamorte C, et al · · 2025 · cited 1× · PMID 41388318 · DOI 10.1186/s13012-025-01469-w
5. Proceedings of the Fifth Biennial Conference of the Society for Implementation Research Collaboration (SIRC) 2019: where the rubber meets the road: the intersection of research, policy, and practice - part 2 : Seattle, WA, USA. 12-14 September 2019.
   · 2020 · PMID 32998745 · DOI 10.1186/s13012-020-01033-8