NCT04170725

Muscular and Cutaneous Dysfunction in POTS

Completed NA Last updated 10 March 2025

What this trial tests

NA trial testing Patient and Healthy Volunteers training protocol in Postural Tachycardia Syndrome in 15 participants. Completed in 3 March 2025.

Timeline

10 January 2020

Primary endpoint
3 March 2025

3 March 2025

Quick facts

Lead sponsor	Insel Gruppe AG, University Hospital Bern
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	treatment
Enrollment	15
Start date	10 January 2020
Primary completion	3 March 2025
Estimated completion	3 March 2025
Sites	1 location across Switzerland

Drugs / interventions tested

• Patient and Healthy Volunteers training protocol

Conditions studied

• Postural Tachycardia Syndrome — all drugs for Postural Tachycardia Syndrome →

Sponsor

Insel Gruppe AG, University Hospital Bern

Who can join

Adults 18 to 60, any sex, with Postural Tachycardia Syndrome. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

POTS patients seem to experience orthostasis-dependent muscle weakness and pain as well as increased muscle fatigue upon physical activity, which can be improved by regular aerobic exercise. However, reduced sweat production of the extremities with limited control of the body temperature leads to exercise intolerance, so that sticking to a training program becomes a challenge for most patients. Recordings of MVRCs provide a new tool to assess muscle membrane dysfunction, depending on ischemia, surface temperature and training. As muscle dysfunction is assumed to be present in the majority of POTS patients but has not yet been scientifically studied the present study aims at understanding the muscular and cutaneous functioning in POTS using MVRC recordings, dependent both on orthostatic stress and exercise training as well as body temperature regulation. Our main hypothesis is that POTS patients experience functional muscle dysfunction that may be linked to altered muscle perfusion or body temperature regulation.

The purpose of this study is to examine muscular and cutaneous dysfunction in POTS in order to i) better understand the underlying pathology for symptoms and to ii) ultimately improve treatment options.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.