Who is sponsoring NCT04310644?

NCT04310644 is sponsored by RWTH Aachen University.

What drugs are being tested in NCT04310644?

Interventions in NCT04310644: No intervention planned, but all patients get our standart treatment.

What condition does NCT04310644 study?

NCT04310644 studies Autonomic Neuropathy, Ehlers-Danlos Syndrome Hypermobility Type, Small Fiber Neuropathy, Postural Tachycardia Syndrome.

Is NCT04310644 still recruiting?

NCT04310644 is currently recruiting now. Last updated 4 February 2025.

Last reviewed 2025-02-04 · How we verify

NCT04310644: ProANS

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Autonomic Small Fiber Neuropathy and Ehlers Danlos Syndromes - Prospective Study and Registry

Recruiting now Last updated 4 February 2025

What this trial tests

trial testing No intervention planned, but all patients get our standart treatment in Autonomic Neuropathy in 200 participants. Currently enrolling.

Timeline

15 September 2019

Primary endpoint
15 September 2028

15 September 2029

Quick facts

Lead sponsor	RWTH Aachen University
Status	Recruiting now
Study type	OBSERVATIONAL
Enrollment	200
Start date	15 September 2019
Primary completion	15 September 2028
Estimated completion	15 September 2029
Sites	1 location across Germany

Drugs / interventions tested

No intervention planned, but all patients get our standart treatment

Conditions studied

Autonomic Neuropathy — all drugs for Autonomic Neuropathy →
Ehlers-Danlos Syndrome Hypermobility Type — all drugs for Ehlers-Danlos Syndrome Hypermobility Type →
Small Fiber Neuropathy — all drugs for Small Fiber Neuropathy →
Postural Tachycardia Syndrome — all drugs for Postural Tachycardia Syndrome →

Sponsor

RWTH Aachen University

Who can join

Adults 18 to 80, any sex, with Autonomic Neuropathy or Ehlers-Danlos Syndrome Hypermobility Type. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

We examine patients with different autonomic neuropathies and Ehlers Danlos syndromes compared to healthy controls at three different points over time (baseline, after 3 months and after 1.5 years) to gain knowledge about the course of this disease and understand its pathophysiology, with a focus on Small Fiber neuropathy. Moreover we will validate the german version of the Malmö POTS Score and establish an easy diagnostic scheme for patients in outpatient care.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Deep abdominal breathing reduces heart rate and symptoms during orthostatic challenge in patients with postural orthostatic tachycardia syndrome.
Stick M, Leone A, Fischer F, Schulz JB, et al · · 2024 · cited 2× · PMID 38962840 · DOI 10.1111/ene.16402
Real-Time Magnetic Resonance Imaging to Study Orthostatic Intolerance Mechanisms in Human Beings: Proof of Concept.
Gerlach DA, Maier A, Manuel J, Bach A, et al · · 2022 · cited 1× · PMID 36300662 · DOI 10.1161/jaha.122.026437

Verify or expand the search:

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04310644 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by RWTH Aachen University
Last refreshed: 4 February 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04310644.

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