NCT04167189 is a EARLY_PHASE1 clinical trial of Lidocaine gel in ADHD, sponsored by PhenoSolve, LLC.

Who is sponsoring NCT04167189?

NCT04167189 is sponsored by PhenoSolve, LLC.

What drugs are being tested in NCT04167189?

Interventions in NCT04167189: Lidocaine gel.

Is NCT04167189 still recruiting?

NCT04167189 is currently completed. Last updated 2 July 2021.

Are results published for NCT04167189?

Yes — primary outcome results have been posted to ClinicalTrials.gov. See the outcomes section above for details.

Last reviewed 2021-07-02 · How we verify

NCT04167189

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Observational Study to Assess the Frequency of Lidocaine Ineffectiveness in Hard-to-treat ADHD

Completed EARLY_PHASE1 Results posted Last updated 2 July 2021

What this trial tests

EARLY_PHASE1 trial testing Lidocaine gel in ADHD in 28 participants. Completed in 30 March 2020.

Timeline

20 January 2018

Primary endpoint
30 March 2020

30 March 2020

Quick facts

Lead sponsor	PhenoSolve, LLC
Phase	EARLY_PHASE1
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	health services research
Enrollment	28
Start date	20 January 2018
Primary completion	30 March 2020
Estimated completion	30 March 2020
Sites	1 location across United States

Drugs / interventions tested

Lidocaine gel

Conditions studied

ADHD — all drugs for ADHD →

Sponsor

PhenoSolve, LLC — full company profile →

Who can join

Adults 7 to 49, any sex, with ADHD. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Observational Study: Number of Participants With Lidocaine Ineffectiveness by Taste Test in Hard-to-treat ADHD Primary · on day of testing, approximately 30 minutes for clinic visit

Subjects will be asked to identify each taste and its intensity.

Group	Value	95% CI
Hard-to-treat ADHD	1
Hard-to-treat ADHD	27

Sponsor's own description

This work will assess the prevalence in hard-to-treat ADHD of the ineffectiveness of the anesthetic Lidocaine.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Lidocaine Ineffectiveness Suggests New Psychopharmacology Drug Target.
Mintz M, Badner V, Feldman LK, Mintz P, et al · · 2022 · cited 1× · PMID 35815177 · DOI 10.64719/pb.4441

Verify or expand the search:

Other trials of Lidocaine gel

Trials testing the same drug.

NCT03676725 — Prevalence of Lidocaine Ineffectiveness in Adults With and Without ADHD · EARLY_PHASE1 · completed
NCT03680885 — Validating a New Non-invasive Approach to Testing Lidocaine Effectiveness · EARLY_PHASE1 · completed
NCT03397082 — Topic Cervical Anesthesia for Pain Control During Endouterine Manual Aspiration · NA · completed

Other recruiting trials for ADHD

Currently open trials in the same condition.

NCT07314333 — A Trial to Assess How Centanafadine Interacts With Stimulants in the Body · Phase 1 · recruiting
NCT07262853 — Dual Executive Function Training Package · NA · recruiting
NCT07291453 — Loving Habits: A Feasibility Study of a Support Program for Building New Parent-child Behavioral Habits · NA · recruiting
NCT07281092 — Comparative Efficacy of Organizational Skills Training (OST) and Mindfulness-Based Intervention (MBI) · NA · recruiting
NCT07219810 — Accelerated iTBS Targeting of Working Memory Versus Inhibitory Control in Adolescent ADHD · NA · recruiting

Other PhenoSolve, LLC trials

Trials by the same sponsor.

NCT04856956 — Testing Pediatric Rheumatology Diagnostic Decision Support in Clinical Use · NA · unknown
NCT03676725 — Prevalence of Lidocaine Ineffectiveness in Adults With and Without ADHD · EARLY_PHASE1 · completed
NCT03680885 — Validating a New Non-invasive Approach to Testing Lidocaine Effectiveness · EARLY_PHASE1 · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04167189 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by PhenoSolve, LLC
Last refreshed: 2 July 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04167189.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing