Last reviewed · How we verify
NCT04166539
Neurotoxicity and Cardiotoxicity in Total Joint Arthroplasty
trial testing Questionnaires in Metallosis in 115 participants. Completed in 27 September 2021.
27 September 2021
Quick facts
| Lead sponsor | Mayo Clinic |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 115 |
| Start date | 1 October 2019 |
| Primary completion | 27 September 2021 |
| Estimated completion | 27 September 2021 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Questionnaires
- Interviews
- Blood draw — full drug profile →
- Magnetic Resonance Imaging
- Echocardiogram
Conditions studied
- Metallosis — all drugs for Metallosis →
- Pain — all drugs for Pain →
- Total Hip Replacement — all drugs for Total Hip Replacement →
- Total Knee Replacement — all drugs for Total Knee Replacement →
Sponsor
Mayo Clinic
Who can join
Adults 18 to 100, any sex, with Metallosis or Pain. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The purpose of this research is to understand whether patients who previously had total hip or total knee replacement experience memory, thinking or heart problems. This study will help us determine if and how often these problems occur.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Blood metal concentrations and cardiac structure and function in total joint arthroplasty patients.
Brennan PC, Peterson SM, O'Byrne TJ, Laporta ML, et al · · 2024 · cited 5× · PMID 39165877 · DOI 10.5312/wjo.v15.i8.773
Verify or expand the search:
- PubMed search for NCT04166539
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04166539 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Mayo Clinic
- Last refreshed: 8 December 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04166539.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing