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NCT04162535

Elucidation of the Mechanisms and Effects of Certain Anesthetic Interventions on Digestive Cancer Patients Subjected to Surgery

Status unknown Phase 1 Last updated 10 February 2021
What this trial tests

Phase 1 trial testing Lidocaine 1% Injectable Solution in Colorectal Cancer in 40 participants. Status unknown.

Timeline
26 November 2018
Primary endpoint
31 December 2023
31 December 2023

Quick facts

Lead sponsorIuliu Hatieganu University of Medicine and Pharmacy
PhasePhase 1
StatusStatus unknown
Study typeINTERVENTIONAL
Allocationrandomized
Designparallel
Maskingsingle
Primary purposebasic science
Enrollment40
Start date26 November 2018
Primary completion31 December 2023
Estimated completion31 December 2023
Sites1 location across Romania

Drugs / interventions tested

Conditions studied

Sponsor

Iuliu Hatieganu University of Medicine and Pharmacy

Who can join

Adults 18 to 80, any sex, with Colorectal Cancer. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Digestive cancers (liver, colonic, pancreatic) have a high incidence and high mortality, their population prevalence is also increasing. Given that the anesthesia techniques and the agents used act directly and indirectly on the immune system during the perioperative period, influencing both the treatment and the prognosis of patients with colorectal cancer who undergo elective interventions, a series of perianesthetic interventions have been proposed in order to reduce morbidity-mortality perioperative.

Publications & conference data

6 peer-reviewed publications reference this trial (live from Europe PMC):

  1. Repositioning Lidocaine as an Anticancer Drug: The Role Beyond Anesthesia.
    Zhou D, Wang L, Cui Q, Iftikhar R, et al · · 2020 · cited 35× · PMID 32766241 · DOI 10.3389/fcell.2020.00565
  2. Local Anesthetics and Recurrence after Cancer Surgery-What's New? A Narrative Review.
    Müller SD, Ziegler JSH, Piegeler T. · · 2021 · cited 19× · PMID 33670434 · DOI 10.3390/jcm10040719
  3. Trial watch: local anesthetics in cancer therapy.
    Carnet Le Provost K, Kepp O, Kroemer G, Bezu L. · · 2024 · cited 5× · PMID 38504848 · DOI 10.1080/2162402x.2024.2308940
  4. Circulating biomarkers in perioperative management of cancer patients.
    Huang Q, Zhou R, Hao X, Zhang W, et al · · 2023 · cited 4× · PMID 37954451 · DOI 10.1093/pcmedi/pbad018
  5. The Effect of Different Anesthetic Techniques on Proliferation, Apoptosis, and Gene Expression in Colon Cancer Cells: A Pilot In Vitro Study.
    Alexa AL, Jurj A, Tomuleasa C, Tigu AB, et al · · 2023 · cited 2× · PMID 36661535 · DOI 10.3390/cimb45010049
  6. Reassessing lidocaine as an electroporation sensitizer in vitro.
    Blažič A, Šmerc R, Polajžer T, Miklavčič D, et al · · 2025 · cited 1× · PMID 40665133 · DOI 10.1038/s41598-025-11695-3

Verify or expand the search:

Other trials of Lidocaine 1% Injectable Solution

Trials testing the same drug.

Other recruiting trials for Colorectal Cancer

Currently open trials in the same condition.

Other Iuliu Hatieganu University of Medicine and Pharmacy trials

Trials by the same sponsor.

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Data sources for this page

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