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NCT04148599
Effect of IV Infusion of Lidocaine Compared to IV Infusion of Dexmedetomidine on Proinflammatory Cytokines
Phase 3 trial testing dexmedetomidine infusion in Inflammatory Response in 54 participants. Completed in 13 June 2020.
10 June 2020
Quick facts
| Lead sponsor | Norma Osama Abdalla Zayed |
|---|---|
| Phase | Phase 3 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | prevention |
| Enrollment | 54 |
| Start date | 2 January 2018 |
| Primary completion | 10 June 2020 |
| Estimated completion | 13 June 2020 |
| Sites | 1 location across Egypt |
Drugs / interventions tested
- dexmedetomidine infusion
- lidocaine infusion — full drug profile →
- Placebos — full drug profile →
Conditions studied
- Inflammatory Response — all drugs for Inflammatory Response →
Sponsor
Norma Osama Abdalla Zayed
Who can join
Adults 18 to 60, any sex, with Inflammatory Response. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study is designed to compare between intravenous infusion of dexmedetomidine and intravenous infusion of lidocaine in reduction of proinflammatory cytokines as IL-6 and TNF-α, some stress reactions (serum insulin and serum lactate),and postoperative analgesic requirements in patients undergoing surgery for pelviabdominal cancers.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Trial watch: dexmedetomidine in cancer therapy.
Carnet Le Provost K, Kepp O, Kroemer G, Bezu L. · · 2024 · cited 24× · PMID 38481729 · DOI 10.1080/2162402x.2024.2327143
Verify or expand the search:
- PubMed search for NCT04148599
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Currently open trials in the same condition.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04148599 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Norma Osama Abdalla Zayed
- Last refreshed: 3 August 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04148599.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing